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Evaluation of TLR4 Inhibitor, T5342126, in Modulation of Ethanol-Drinking Behavior in Alcohol-Dependent Mice.

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      Abstract

      Several lines of evidence support a critical role of TLR4 in the neuroimmune responses associated with alcohol disorders and propose inhibitors of TLR4 signaling as potential treatments for alcoholism. In this work, we investigated the effect of T5342126 compound, a selective TLR4 inhibitor, on excessive drinking and microglial activation associated with ethanol dependence.

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      Affiliations
      [1 ] Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA.
      [2 ] Molecular and Cellular Neuroscience, The Scripps Research Institute, La Jolla, CA 92037, USA.
      [3 ] Department of Chemistry and Biochemistry, BioFrontiers Institute, University of Colorado Boulder, Boulder, CO 80309, USA.
      [4 ] Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, CA 92037, USA mroberto@scripps.edu.
      Journal
      Alcohol Alcohol.
      Alcohol and alcoholism (Oxford, Oxfordshire)
      Oxford University Press (OUP)
      1464-3502
      0735-0414
      Sep 2016
      : 51
      : 5
      27151970 agw026 10.1093/alcalc/agw026 5004745

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