There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Several lines of evidence support a critical role of TLR4 in the neuroimmune responses
associated with alcohol disorders and propose inhibitors of TLR4 signaling as potential
treatments for alcoholism. In this work, we investigated the effect of T5342126 compound,
a selective TLR4 inhibitor, on excessive drinking and microglial activation associated
with ethanol dependence.