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      Safety of statins: focus on clinical pharmacokinetics and drug interactions.

      1 , ,
      Circulation
      Ovid Technologies (Wolters Kluwer Health)

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          Abstract

          Statin monotherapy is generally well tolerated, with a low frequency of adverse events. The most important adverse effects associated with statins are myopathy and an asymptomatic increase in hepatic transaminases, both of which occur infrequently. Because statins are prescribed on a long-term basis, however, possible interactions with other drugs deserve particular attention, as many patients will typically receive pharmacological therapy for concomitant conditions during the course of statin treatment. This review summarizes the pharmacokinetic properties of statins and emphasizes their clinically relevant drug interactions.

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          Author and article information

          Journal
          Circulation
          Circulation
          Ovid Technologies (Wolters Kluwer Health)
          1524-4539
          0009-7322
          Jun 15 2004
          : 109
          : 23 Suppl 1
          Affiliations
          [1 ] Department of Pharmacological Sciences, University of Milan, Milan, Italy.
          Article
          109/23_suppl_1/III-50
          10.1161/01.CIR.0000131519.15067.1f
          15198967
          f351b676-e10b-4226-9a33-44fec10eabd2
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