Celiac Disease and Autoimmunity: Review and Controversies

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Abstract

Celiac disease (CD) is an autoimmune condition affecting the small intestine, triggered by the ingestion of gluten, the protein fraction of wheat, barley, and rye. There is a strong linkage between CD and HLA-DQ2 and HLA-DQ8 haplotypes. Multiple case reports and small series suggest concordance between CD and other autoimmune disorders. This paper provides a brief overview of the pathogenesis of CD and reviews the literature regarding associations between CD and other autoimmune diseases, including the potential effects of gluten-free diet therapy on the prevention or amelioration of associated diseases.

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Most cited references 90

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Shared and distinct genetic variants in type 1 diabetes and celiac disease.

Deborah J Smyth, Vincent Plagnol, Neil M Walker … (2009)

Two inflammatory disorders, type 1 diabetes and celiac disease, cosegregate in populations, suggesting a common genetic origin. Since both diseases are associated with the HLA class II genes on chromosome 6p21, we tested whether non-HLA loci are shared. We evaluated the association between type 1 diabetes and eight loci related to the risk of celiac disease by genotyping and statistical analyses of DNA samples from 8064 patients with type 1 diabetes, 9339 control subjects, and 2828 families providing 3064 parent-child trios (consisting of an affected child and both biologic parents). We also investigated 18 loci associated with type 1 diabetes in 2560 patients with celiac disease and 9339 control subjects. Three celiac disease loci--RGS1 on chromosome 1q31, IL18RAP on chromosome 2q12, and TAGAP on chromosome 6q25--were associated with type 1 diabetes (P<1.00x10(-4)). The 32-bp insertion-deletion variant on chromosome 3p21 was newly identified as a type 1 diabetes locus (P=1.81x10(-8)) and was also associated with celiac disease, along with PTPN2 on chromosome 18p11 and CTLA4 on chromosome 2q33, bringing the total number of loci with evidence of a shared association to seven, including SH2B3 on chromosome 12q24. The effects of the IL18RAP and TAGAP alleles confer protection in type 1 diabetes and susceptibility in celiac disease. Loci with distinct effects in the two diseases included INS on chromosome 11p15, IL2RA on chromosome 10p15, and PTPN22 on chromosome 1p13 in type 1 diabetes and IL12A on 3q25 and LPP on 3q28 in celiac disease. A genetic susceptibility to both type 1 diabetes and celiac disease shares common alleles. These data suggest that common biologic mechanisms, such as autoimmunity-related tissue damage and intolerance to dietary antigens, may be etiologic features of both diseases. 2008 Massachusetts Medical Society

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Author and article information

Contributors

Jolanda M. Denham: +1-614-7223450 , +1-614-7223454 , Jolanda.denham@nationwidechildrens.org

Journal

Journal ID (nlm-ta): Curr Allergy Asthma Rep

Journal ID (iso-abbrev): Curr Allergy Asthma Rep

Title: Current Allergy and Asthma Reports

Publisher: Springer US (Boston )

ISSN (Print): 1529-7322

ISSN (Electronic): 1534-6315

Publication date (Electronic): 17 May 2013

Publication date PMC-release: 17 May 2013

Publication date (Print): 2013

Volume: 13

Pages: 347-353

Affiliations

Nationwide Children’s Hospital, The Ohio State University School of Medicine, 700 Children’s Drive, Columbus, OH 43205 USA

Article

Publisher ID: 352

DOI: 10.1007/s11882-013-0352-1

PMC ID: 3725235

PubMed ID: 23681421

SO-VID: f35e13e1-1d1a-4646-9833-e83b83ca00b3

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Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.

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ScienceOpen disciplines: Immunology

Keywords: celiac,celiac disease,autoimmune,addison’s disease,addison’s,type 1 diabetes,autoimmune thyroiditis,hashimoto’s thyroiditis,graves disease,cryptogenic hepatitis,celiac hepatitis,primary biliary cirrhosis,sjogren’s syndrome,systemic lupus erythematous,sle,lupus,antiphospholipid syndrome,psoriasis,vitiligo,alopecia acreta,dermatitis herpetiformis

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ScienceOpen disciplines: Immunology

Keywords: celiac, celiac disease, autoimmune, addison’s disease, addison’s, type 1 diabetes, autoimmune thyroiditis, hashimoto’s thyroiditis, graves disease, cryptogenic hepatitis, celiac hepatitis, primary biliary cirrhosis, sjogren’s syndrome, systemic lupus erythematous, sle, lupus, antiphospholipid syndrome, psoriasis, vitiligo, alopecia acreta, dermatitis herpetiformis

Celiac Disease and Autoimmunity: Review and Controversies

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Abstract

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Regulatory T cell (Treg) therapy

Most cited references 90

Shared and distinct genetic variants in type 1 diabetes and celiac disease.

The antiphospholipid syndrome.

Chronic autoimmune thyroiditis.

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