50
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      A Prospective, Randomized Double-Blind, Placebo-Controlled Study of Safety and Efficacy of a High-Concentration Full-Spectrum Extract of Ashwagandha Root in Reducing Stress and Anxiety in Adults

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Context:

          Stress is a state of mental or emotional strain or tension, which can lead to underperformance and adverse clinical conditions. Adaptogens are herbs that help in combating stress. Ayurvedic classical texts, animal studies and clinical studies describe Ashwagandha as a safe and effective adaptogen.

          Aims:

          The aim of the study was to evaluate the safety and efficacy of a high-concentration full-spectrum extract of Ashwagandha roots in reducing stress and anxiety and in improving the general well-being of adults who were under stress.

          Settings and Design:

          Single center, prospective, double-blind, randomized, placebo-controlled trial.

          Materials and Methods:

          A total of 64 subjects with a history of chronic stress were enrolled into the study after performing relevant clinical examinations and laboratory tests. These included a measurement of serum cortisol, and assessing their scores on standard stress-assessment questionnaires. They were randomized to either the placebo control group or the study drug treatment group, and were asked to take one capsule twice a day for a period of 60 days. In the study drug treatment group, each capsule contained 300 mg of high-concentration full-spectrum extract from the root of the Ashwagandha plant. During the treatment period (on Day 15, Day 30 and Day 45), a follow-up telephone call was made to all subjects to check for treatment compliance and to note any adverse reactions. Final safety and efficacy assessments were done on Day 60.

          Statistical Analysis:

          t-test, Mann-Whitney test.

          Results:

          The treatment group that was given the high-concentration full-spectrum Ashwagandha root extract exhibited a significant reduction ( P<0.0001) in scores on all the stress-assessment scales on Day 60, relative to the placebo group. The serum cortisol levels were substantially reduced ( P=0.0006) in the Ashwagandha group, relative to the placebo group. The adverse effects were mild in nature and were comparable in both the groups. No serious adverse events were reported.

          Conclusion:

          The findings of this study suggest that a high-concentration full-spectrum Ashwagandha root extract safely and effectively improves an individual's resistance towards stress and thereby improves self-assessed quality of life.

          Related collections

          Most cited references16

          • Record: found
          • Abstract: not found
          • Book: not found

          Manual for the Depression, Anxiety, Stress Scales

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Measuring the dimension of psychological general well-being by the WHO-5

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress.

              Withania somnifera (WS) Dunal is classified in Ayurveda, the ancient Hindu system of medicine, as a rasayana, a group of plant-derived drugs reputed to promote physical and mental health, augment resistance of the body against disease and diverse adverse environmental factors, revitalise the body in debilitated conditions and increase longevity. These attributes are remarkably similar to the properties ascribed to adaptogens like Panax ginseng (PG) in contemporary medicine. As such, the adaptogenic activity of a standardised extract of WS roots was investigated against a rat model of chronic stress (CS). The stress procedure was mild, unpredictable footshock, administered once daily for 21 days to adult male Wistar rats. CS induced significant hyperglycaemia, glucose intolerance, increase in plasma corticosterone levels, gastric ulcerations, male sexual dysfunction, cognitive deficits, immunosuppression and mental depression. These CS induced perturbations were attenuated by WS (25 and 50 mg/kg po) and by PG (100 mg/kg po), administered 1 h before footshock for 21 days. The results indicate that WS, like PG, has significant antistress adaptogenic activity, confirming the clinical use of the plant in Ayurveda.
                Bookmark

                Author and article information

                Journal
                Indian J Psychol Med
                Indian J Psychol Med
                IJPsyM
                Indian Journal of Psychological Medicine
                Medknow Publications & Media Pvt Ltd (India )
                0253-7176
                0975-1564
                Jul-Sep 2012
                : 34
                : 3
                : 255-262
                Affiliations
                [1]Department of Neuropsychiatry and Geriatric Psychiatry, Asha Hospital, Hyderabad, Andhra Pradesh, India
                [1 ]Ayurveda, Ashwins Health Care and Research Centre, Hyderabad, Andhra Pradesh, India
                Author notes
                Address for correspondence: Dr. K. Chandrasekhar, Department of Neuropsychiatry, Asha Hospital, Road No. 14, 298, Banjara Hills, Hyderabad - 500 034, Andhra Pradesh, India. E-mail: kcsekhar56@ 123456yahoo.co.in
                Article
                IJPsyM-34-255
                10.4103/0253-7176.106022
                3573577
                23439798
                f3678d3f-dc55-472d-8bdf-94f56eb6f5fd
                Copyright: © Indian Journal of Psychological Medicine

                This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                Categories
                Original Article

                Clinical Psychology & Psychiatry
                adaptogen,high-concentration full-spectrum ashwagandha root extract,stress,withania somnifera

                Comments

                Comment on this article