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      Moderate Metabolic Acidosis and Its Effects on Serum Parameters in Hemodialysis Patients

      , ,

      Nephron

      S. Karger AG

      Albumin, Metabolic acidosis, Hemodialysis, Blood urea nitrogen

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          Abstract

          We screened the laboratory data of 50 chronic hemodialysis patients selected randomly over a 21-month period to generate 158 data points which identified two groups: (1) those with a predialysis total CO<sub>2</sub> concentration less than or equal to 19 mEq/l (data A; n = 57) and (2) those with a predialysis total CO<sub>2</sub> concentration greater than 19 mEq/l (data B; n = 101). Then, both groups were compared for the following parameters: predialysis blood urea nitrogen (BUN), serum phosphorus, uric acid, creatinine, and albumin concentrations, Kt/V, urea reduction ratio, normalized protein catabolic rate, dry weight, ultrafiltration, blood flow and dialysis flow rates, duration of dialysis treatment, and blood pressure. Group data A had significantly higher predialysis BUN, phosphorus, and uric acid concentrations than group data B. There were significant inverse correlations between predialysis serum bicarbonate and predialysis BUN, phosphorus, and uric acid concentrations. Although it is not clear what the long term side effects of moderate metabolic acidosis are, we recommend its correction.

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          Author and article information

          Journal
          NEF
          Nephron
          10.1159/issn.1660-8151
          Nephron
          S. Karger AG
          1660-8151
          2235-3186
          2000
          October 2000
          22 September 2000
          : 86
          : 2
          : 135-138
          Affiliations
          Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, Washington, D.C., USA
          Article
          45731 Nephron 2000;86:135–138
          10.1159/000045731
          11014982
          © 2000 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Figures: 3, Tables: 1, References: 14, Pages: 4
          Product
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/45731
          Categories
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hemodialysis, Albumin, Metabolic acidosis, Blood urea nitrogen

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