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      Moderate Metabolic Acidosis and Its Effects on Serum Parameters in Hemodialysis Patients

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      S. Karger AG

      Albumin, Metabolic acidosis, Hemodialysis, Blood urea nitrogen

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          We screened the laboratory data of 50 chronic hemodialysis patients selected randomly over a 21-month period to generate 158 data points which identified two groups: (1) those with a predialysis total CO<sub>2</sub> concentration less than or equal to 19 mEq/l (data A; n = 57) and (2) those with a predialysis total CO<sub>2</sub> concentration greater than 19 mEq/l (data B; n = 101). Then, both groups were compared for the following parameters: predialysis blood urea nitrogen (BUN), serum phosphorus, uric acid, creatinine, and albumin concentrations, Kt/V, urea reduction ratio, normalized protein catabolic rate, dry weight, ultrafiltration, blood flow and dialysis flow rates, duration of dialysis treatment, and blood pressure. Group data A had significantly higher predialysis BUN, phosphorus, and uric acid concentrations than group data B. There were significant inverse correlations between predialysis serum bicarbonate and predialysis BUN, phosphorus, and uric acid concentrations. Although it is not clear what the long term side effects of moderate metabolic acidosis are, we recommend its correction.

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          Author and article information

          S. Karger AG
          October 2000
          22 September 2000
          : 86
          : 2
          : 135-138
          Division of Renal Diseases and Hypertension, Department of Medicine, George Washington University Medical Center, Washington, D.C., USA
          45731 Nephron 2000;86:135–138
          © 2000 S. Karger AG, Basel

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          Page count
          Figures: 3, Tables: 1, References: 14, Pages: 4
          Self URI (application/pdf): https://www.karger.com/Article/Pdf/45731
          Original Paper

          Cardiovascular Medicine, Nephrology

          Hemodialysis, Albumin, Metabolic acidosis, Blood urea nitrogen


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