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      Is Open Access

      Urothelial carcinoma of the bladder presenting with abnormal inguinal metastasis

      case-report
      Author(s): , *
      Publication date (Electronic):
      Journal: Urology Case Reports
      Publisher: Elsevier

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          Abstract

          Inguinal lymph node metastasis in urothelial carcinoma is exceptionally rare. Here, We report a case of bladder cancer with inguinal lymph node metastasis and, through searching our hospital's database, identified two additional similar patients managed at our center since 1990. All patients underwent PET/CT scans, and in two cases, inguinal lymph node biopsies confirmed metastatic urothelial carcinoma. One elderly female presented with inguinal lymph node metastasis as the initial sign of recurrence. This report underscores the increased risk of distant metastasis and highlights the critical need for vigilant monitoring of patients with recurrent bladder cancer following repeated TURBT procedures.

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          Most cited references7

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          Advances in diagnosis and treatment of bladder cancer.

          Antonio Lopez-Beltran, Michael S Cookson, Brendan J Guercio … (2024)
          Bladder cancer remains a leading cause of cancer death worldwide and is associated with substantial impacts on patient quality of life, morbidity, mortality, and cost to the healthcare system. Gross hematuria frequently precedes the diagnosis of bladder cancer. Non-muscle-invasive bladder cancer (NMIBC) is managed initially with transurethral resection of a bladder tumor (TURBT), followed by a risk stratified approach to adjuvant intravesical therapy (IVe), and is associated with an overall survival of 90%. However, cure rates remain lower for muscle invasive bladder cancer (MIBC) owing to a variety of factors. NMIBC and MIBC groupings are heterogeneous and have unique pathological and molecular characteristics. Indeed, The Cancer Genome Atlas project identified genetic drivers and luminal and basal molecular subtypes of MIBC with distinct treatment responses. For NMIBC, IVe immunotherapy (primarily BCG) is the gold standard treatment for high grade and high risk NMIBC to reduce or prevent both recurrence and progression after initial TURBT; novel trials incorporate immune checkpoint inhibitors. IVe gene therapy and combination IVe chemotherapy have recently been completed, with promising results. For localized MIBC, essential goals are improving care and reducing morbidity following cystectomy or bladder preserving strategies. In metastatic disease, advances in understanding of the genomic landscape and tumor microenvironment have led to the implementation of immune checkpoint inhibitors, targeted treatments, and antibody-drug conjugates. Defining better selection criteria to identify the patients most likely to benefit from a specific treatment is an urgent need.
          Article 0 comments Cited 73 times – based on 0 reviews     Review now
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            Diagnosis and Treatment of Non-Muscle Invasive Bladder Cancer: AUA/SUO Guideline: 2024 Amendment

            Jeffrey M. Holzbeierlein, Brooke R. Bixler, David I. Buckley … (2024)
            Article 0 comments Cited 27 times – based on 0 reviews     Review now
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              A pictorial review of bladder cancer nodal metastases

              Prasad R. Shankar, Daniel Barkmeier, Lubomir Hadjiiski … (2018)
              Lymph node involvement in bladder cancer is common and has prognostic implications. Early and accurate identification of metastatic lymph nodes is, therefore, important in ensuring appropriate patient triage and management. The purpose of this review is to provide a pictorial and educational overview of the staging and imaging appearance of metastatic lymph nodes in bladder cancer. Additionally, a secondary aim of this manuscript is to provide a review of the diagnostic accuracy of common imaging modalities available for detecting metastatic lymph nodes in affected patients.
              Article 0 comments Cited 12 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Hongyu Wang
                Surong Hua
                Journal
                Journal ID (nlm-ta): Urol Case Rep
                Journal ID (iso-abbrev): Urol Case Rep
                Title: Urology Case Reports
                Publisher: Elsevier
                ISSN (Electronic): 2214-4420
                Publication date PMC-release: 10 February 2025
                Publication date Collection: March 2025
                Publication date (Electronic): 10 February 2025
                Volume: 59
                Electronic Location Identifier: 102983
                Affiliations
                [1]Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, 1# Shuaifuyuan, Dongcheng District, Beijing, 100730, China
                Author notes
                [* ]Corresponding author. No.1 Shuai Fu Yuan, Dongcheng District, Beijing, 100730, China. huasurong@ 123456tsinghua.org.cn
                Article
                Publisher Item ID: S2214-4420(25)00054-3 Publisher ID: 102983
                DOI: 10.1016/j.eucr.2025.102983
                PMC ID: 11872458
                PubMed ID: 40027079
                SO-VID: f3862b80-7ca8-4d64-97f4-2c60c5882a1f
                Copyright © © 2025 The Authors
                License:

                This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

                History
                Date received : 2 January 2025
                Date revision received : 5 February 2025
                Date accepted : 8 February 2025
                Categories
                Subject: Oncology

                Data availability:

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