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      Common pitfalls in nanotechnology: lessons learned from NCI's Nanotechnology Characterization Laboratory.

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          Abstract

          The Nanotechnology Characterization Laboratory's (NCL) unique set-up has allowed our lab to handle and test a variety of nanoparticle platforms intended for the delivery of cancer therapeutics and/or imaging contrast agents. Over the last six years, the NCL has characterized more than 250 different nanomaterials from more than 75 different investigators. These submitted nanomaterials stem from a range of backgrounds and experiences, including government, academia and industry. This has given the NCL a unique and valuable opportunity to observe trends in nanoparticle safety and biocompatibility, as well as note some of the common mistakes and oversights of nanoformulation. While not exhaustive, this article aims to share some of the most common pitfalls observed by the NCL as they relate to nanoparticle synthesis, purification, characterization and analysis.

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          Author and article information

          Journal
          Integr Biol (Camb)
          Integrative biology : quantitative biosciences from nano to macro
          1757-9708
          1757-9694
          Jan 2013
          : 5
          : 1
          Affiliations
          [1 ] Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.
          Article
          NIHMS393670
          10.1039/c2ib20117h
          22772974

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