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      Deformity correction and extremity lengthening in the lower leg: comparison of clinical outcomes with two external surgical procedures

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          Abstract

          Objective

          Distraction osteogenesis is a method of stimulating the growth of new bone tissue in order to lengthen the extremities or bridge resected bone defects. In addition to the now-established intramedullary procedures, two different fixator systems are in use. The present study investigated the classical Ilizarov ring fixator (IRF) and a hexapod to assess the precision of lower-leg lengthening and complications classified using the Paley criteria for problems, obstacles, and complications. The study also examined the follow-up results in functional tests to assess outcomes in terms of range of motion in adjacent joints, daily activities, and quality of life.

          Patients and methods

          A total of 43 patients (53 segments) who were treated over a period of 16 years were re-assessed. In 33 segments, treatment was carried out with the hexapod Taylor Spatial Frame (TSF); the conventional IRF was used in 20 segments. The patients’ mean age was 13.5 years (range 2–54 years). The follow-up examinations were carried out 2–15 years postoperatively and comprised measurement of a current leg axis view with the patient standing, calculation of a knee score, activity scores, ankle joint scores, and assessment of motor function and sensory function using appropriate scores in the lower leg and foot. The post-treatment health-related quality of life was assessed using the Short-Form Health Survey-36 questionnaire.

          Results

          Using the Paley criteria, far fewer problems occurred in the TSF group in comparison with the IRF (TSF 12.1%, IRF 50%). In the problems category, significant differences were observed with regard to axial deviation (TSF 0%, IRF 36.8%) and pin infections (TSF 9.1%, IRF 40%). Comparison of the obstacles and complications did not identify any significant differences between the two groups. Analysis of the scores for the knee, activity, and motor function/sensory function also did not show any marked discrepancies, apart from a major difference in mobility in the upper and lower ankle joints with poorer findings in the TSF group.

          Conclusions

          During treatment, the TSF ring fixator leads to fewer problems, fewer secondary axial translations, and fewer pin infections. However, with temporary transfixation of the ankle joints, the TSF system is also associated with postoperative deterioration in mobility in the upper and lower ankle joint.

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          Most cited references27

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          The tension-stress effect on the genesis and growth of tissues: Part II. The influence of the rate and frequency of distraction.

          To assess the influence of both the rate and the frequency of distraction on osteogenesis during limb elongation, a canine tibia was used with various combinations of distraction rates (0.5 mm, 1.0 mm, or 2.0 mm per day) and distraction frequencies (one step per day, four steps per day, 60 steps per day). The distractions were performed after both open osteotomy and closed osteoclasis. Histomorphic and biochemical studies were conducted on the elongated osseous tissue, fascia, skeletal muscle, smooth muscle, blood vessels, nerves, and skin. It was determined that distraction at a rate of 0.5 mm per day often led to premature consolidation of the lengthening bone, while a distraction rate of 2.0 mm per day often resulted in undesirable changes within elongating tissues. A distraction rate of 1.0 mm per day led to the best results. It was also observed that the greater the distraction frequency, the better the outcome. With optimum preservation of periosseous tissues, bone marrow, and blood supply at the time of osteotomy, stability of external fixation, and 1.0 mm per day of distraction in four steps, osteogenesis within the distraction gap of an elongating bone takes place by the formation of a physislike structure, in which new bone forms in parallel columns extending in both directions from a central growth zone. The growth plate that forms under the influence of tension-stress has features of both physeal and intramembranous ossification, yet is neither; instead, the distraction regenerated bone is unique, providing numerous applications in clinical traumatology, orthopedics, and other medical disciplines.
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            The tension-stress effect on the genesis and growth of tissues. Part I. The influence of stability of fixation and soft-tissue preservation.

            To evaluate the optimum conditions for osteogenesis during limb lengthening and to study the changes in soft tissues undergoing elongation, a series of experiments were performed on the canine tibia. The experiments used the transfixion-wire, Ilizarov circular external skeletal fixator in configurations of differing stability of fixation in combination with a second variable, i.e., preservation of the periosteum, bone marrow, and medullary blood supply. Both increased fixator stability, and maximum preservation of the periosseous and intraosseous soft tissues enhanced bone formation during limb lengthening. To assess the role that the direction of the elongation vector plays in osteogenesis, canine tibiae were widened rather than lengthened in a second series of experiments using an Ilizarov apparatus modified for lateral distraction. The new bone formed parallel to the tension vector even when perpendicular to the bone's mechanical axis. As in longitudinal lengthening, damage to the bone marrow inhibits osteogenesis occurring by the influence of a lateral tension-stress vector. In a third series of experiments, half- and full-circumference cortical defects were created in canine tibiae to study the osteogenic potential of the marrow. New bone formed rapidly, even when the marrow was separated from the surrounding periosseous soft tissues by a sheet of polyvinyl chloride, attesting to the importance of marrow element preservation during osteotomy for limb lengthening.
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              Problems, obstacles, and complications of limb lengthening by the Ilizarov technique.

              D Paley (1989)
              Difficulties that occur during limb lengthening were subclassified into problems, obstacles, and complications. Problems represented difficulties that required no operative intervention to resolve, while obstacles represented difficulties that required an operative intervention. All intraoperative injuries were considered true complications, and all problems during limb lengthening that were not resolved before the end of treatment were considered true complications. The difficulties that occurred during limb lengthening include muscle contractures, joint luxation, axial deviation, neurologic injury, vascular injury, premature consolidation, delayed consolidation, nonunion, pin site problems, and hardware failure. Late complications are those of loss of length, late bowing, and refracture. Joint stiffness may also be a permanent residual complication. Pain and difficulty sleeping are other problems that arise during limb lengthening, especially in the more extensive cases. Forty-six patients had 60 limb segments lengthened between 1.0 and 16.0 cm, with a mean of 5.6 cm. The average treatment time was approximately one month per centimeter for single-level lengthenings with no deformity and 1.2 months per centimeter with deformity correction. The lengthening index for double-level lengthening was 0.57 month per centimeter with no deformity and 0.90 month per centimeter with correction of deformity. In adults, the lengthening index was 1.7 months per centimeter for single-level and 1.1 months per centimeter for double-level lengthening. There were 35 problems that had to be resolved in the outpatient clinic. There were 11 obstacles that required additional operative intervention to resolve. There were 27 true complications, of which 17 were considered minor and ten were considered major complications. Of the major complications, three interfered with achieving the original goals of treatment. All three required further operative intervention to achieve the original goal. These were nonunion in one and late bowing in two. Despite these problems, obstacles, and complications, the original goals of surgery were achieved in 57 of the 60 limb segments treated. Patient satisfaction was achieved in 94% of 46 cases.
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                Author and article information

                Contributors
                eugenreitenbach@gmx.de
                robert.roedl@ukmuenster.de
                georg.gosheger@ukmuenster.de
                bjoern.vogt@ukmuenster.de
                f.schiedel@clemenshospital.de
                Journal
                Springerplus
                Springerplus
                SpringerPlus
                Springer International Publishing (Cham )
                2193-1801
                24 November 2016
                24 November 2016
                2016
                : 5
                : 1
                : 2003
                Affiliations
                [1 ]Department of Orthopaedics, Klinikum Dortmund GmbH, Klinikzentrum Mitte, Dortmund, Germany
                [2 ]Department of General Orthopaedics and Tumor Orthopaedics, Münster University Hospital, Münster, Germany
                [3 ]Department of Pediatric Orthopaedics, Deformity Correction and Foot Surgery, Münster University Hospital, Münster, Germany
                [4 ]Clemenshospital Muenster, Dept. of Pediatric Orthopedics and Deformity Correction, Muenster, Germany
                Article
                3666
                10.1186/s40064-016-3666-3
                5121109
                27933259
                f3ad0183-1396-4dcb-bc34-0137921f9960
                © The Author(s) 2016

                Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License ( http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

                History
                : 15 April 2016
                : 8 November 2016
                Categories
                Case Study
                Custom metadata
                © The Author(s) 2016

                Uncategorized
                deformity correction,extremity lengthening,ilizarov ring fixator,taylor spatial frame

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