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      Regulation of gene expression in lymphocytes and antigen-presenting cells by measles virus: consequences for immunomodulation.

      Journal of Molecular Medicine (Berlin, Germany)
      Animals, Antigen-Presenting Cells, immunology, metabolism, virology, Gene Expression Regulation, Viral, Humans, Immune Tolerance, genetics, Lymphocytes, Measles virus

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          Abstract

          Acute measles, a well known disease usually contracted during early childhood, is still the major cause of vaccine-preventable infant deaths worldwide. There are about 40 million cases of acute measles per year, with more than one million cases of infant death as a consequence of measles. These are mainly due to opportunistic infections which develop on the basis of a generalized suppression of the cellular immunity in the course and after the acute disease. Lymphopenia, a general proliferative unresponsiveness of T cells ex vivo and cytokine imbalance, are considered as major hallmarks of measles virus (MV) induced immunosuppression. These findings are compatible with modulation of T cell responses by viral interference with professional antigen-presenting cells such as dendritic cells or direct effects on T cells by suppression of survival or proliferation signals. In vitro, MV interaction causes a variety of effects on dendritic cells, including maturation and loss of their allostimulatory functions. Whether there is an additional impact on the quality of T cell responses is unknown as yet. It is clear, however, that surface interaction of lymphocytes with the MV glycoprotein complex is necessary and sufficient to induce a state of proliferative unresponsiveness in T cells. This surface contact mediated signal essentially interferes with the propagation of the interleukin 2 receptor signal by blocking the activation of the protein kinase B, also called Akt kinase, both in vitro and after experimental infection.

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          Author and article information

          Journal
          11907644
          10.1007/s00109-001-0299-x

          Chemistry
          Animals,Antigen-Presenting Cells,immunology,metabolism,virology,Gene Expression Regulation, Viral,Humans,Immune Tolerance,genetics,Lymphocytes,Measles virus

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