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      Antiarrhythmic drugs for out-of-hospital cardiac arrest with refractory ventricular fibrillation

      review-article
      Author(s): 1 , 2 , , 2 , 3
      Publication date (Electronic):
      Journal: Critical Care
      Publisher: BioMed Central

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          Abstract

          This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency medicine 2017. Other selected articles can be found online at http://ccforum.com/series/annualupdate2017. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.

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          Most cited references32

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          Regional variation in out-of-hospital cardiac arrest incidence and outcome.

          Graham Nichol, Elizabeth Thomas, Clifton Callaway … (2008)
          The health and policy implications of regional variation in incidence and outcome of out-of-hospital cardiac arrest remain to be determined. To evaluate whether cardiac arrest incidence and outcome differ across geographic regions. Prospective observational study (the Resuscitation Outcomes Consortium) of all out-of-hospital cardiac arrests in 10 North American sites (8 US and 2 Canadian) from May 1, 2006, to April 30, 2007, followed up to hospital discharge, and including data available as of June 28, 2008. Cases (aged 0-108 years) were assessed by organized emergency medical services (EMS) personnel, did not have traumatic injury, and received attempts at external defibrillation or chest compressions or resuscitation was not attempted. Census data were used to determine rates adjusted for age and sex. Incidence rate, mortality rate, case-fatality rate, and survival to discharge for patients assessed or treated by EMS personnel or with an initial rhythm of ventricular fibrillation. Among the 10 sites, the total catchment population was 21.4 million, and there were 20,520 cardiac arrests. A total of 11,898 (58.0%) had resuscitation attempted; 2729 (22.9% of treated) had initial rhythm of ventricular fibrillation or ventricular tachycardia or rhythms that were shockable by an automated external defibrillator; and 954 (4.6% of total) were discharged alive. The median incidence of EMS-treated cardiac arrest across sites was 52.1 (interquartile range [IQR], 48.0-70.1) per 100,000 population; survival ranged from 3.0% to 16.3%, with a median of 8.4% (IQR, 5.4%-10.4%). Median ventricular fibrillation incidence was 12.6 (IQR, 10.6-5.2) per 100,000 population; survival ranged from 7.7% to 39.9%, with a median of 22.0% (IQR, 15.0%-24.4%), with significant differences across sites for incidence and survival (P<.001). In this study involving 10 geographic regions in North America, there were significant and important regional differences in out-of-hospital cardiac arrest incidence and outcome.
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            European Resuscitation Council Guidelines for Resuscitation 2015: Section 3. Adult advanced life support.

            Jasmeet Soar, Jerry P Nolan, Bernd W Böttiger … (2015)
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              Amiodarone, Lidocaine, or Placebo in Out-of-Hospital Cardiac Arrest.

              Peter Kudenchuk, Siobhan P Brown, Mohamud Daya … (2016)
              Antiarrhythmic drugs are used commonly in out-of-hospital cardiac arrest for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia, but without proven survival benefit.
              Article 0 comments Cited 112 times – based on 0 reviews     Review now
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                Author and article information

                Contributors
                Takashi Tagami: t-tagami@nms.ac.jp
                Hideo Yasunaga: yasunagah-tky@umin.ac.jp
                Hiroyuki Yokota: yokota@nms.ac.jp
                Journal
                Journal ID (nlm-ta): Crit Care
                Title: Critical Care
                Publisher: BioMed Central (London )
                ISSN (Print): 1364-8535
                ISSN (Electronic): 1466-609X
                Publication date (Electronic): 21 March 2017
                Publication date PMC-release: 21 March 2017
                Publication date Collection: 2017
                Volume: 21
                Electronic Location Identifier: 59
                Affiliations
                [1 ]ISNI 0000 0001 2173 8328, GRID grid.410821.e, Department of Emergency and Critical Care Medicine, , Nippon Medical School, Tama Nagayama Hospital, ; 2068512 Tama-shi, Tokyo Japan
                [2 ]ISNI 0000 0001 2151 536X, GRID grid.26999.3d, Department of Clinical Epidemiology and Health Economics, , The University of Tokyo, School of Public Health, Graduate School of Medicine, ; 1138555 Bunkyo-ku, Tokyo Japan
                [3 ]ISNI 0000 0001 2173 8328, GRID grid.410821.e, Department of Emergency and Critical Care Medicine, , Nippon Medical School, ; 1138603 Bunkyo-ku, Tokyo Japan
                Article
                Publisher ID: 1639
                DOI: 10.1186/s13054-017-1639-8
                PMC ID: 5360060
                PubMed ID: 28320450
                SO-VID: f3b11ea7-da11-478a-83d9-ae2655ffad38
                Copyright © © Tagami et al. 2017
                History
                Categories
                Subject: Review
                Custom metadata
                issue-copyright-statement © The Author(s) 2017

                ScienceOpen disciplines: Emergency medicine & Trauma
                Data availability:
                ScienceOpen disciplines: Emergency medicine & Trauma

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