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      Gold nanoparticle-based activatable probe for sensing ultralow levels of prostate-specific antigen.

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          Abstract

          It is still in high demand to develop extremely sensitive and accurate clinical tools for biomarkers of interest for early diagnosis and monitoring of diseases. In this report, we present a highly sensitive and compatible gold nanoparticle (AuNP)-based fluorescence-activatable probe for sensing ultralow levels of prostate-specific antigen (PSA) in patient serum samples. The limit of detection of the newly developed probe for PSA was pushed down to 0.032 pg/mL, which is more than 2 orders of magnitude lower than that of the conventional fluorescence probe. The ultrahigh sensitivity of this probe was attributed to the high loading efficiency of the dyes on AuNP surfaces and high fluorescence quenching-unquenching abilities of the dye-AuNP pairs. The efficiency and robustness of this probe were investigated in patient serum samples, demonstrating the great potential of this probe in real-world applications.

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          Author and article information

          Journal
          ACS Nano
          ACS nano
          1936-086X
          1936-0851
          Jun 25 2013
          : 7
          : 6
          Affiliations
          [1 ] Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland 20892, USA.
          Article
          NIHMS483791
          10.1021/nn401837q
          23683064
          f3c04b35-1bc4-45c0-87b3-d9a92fcbab9c
          History

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