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      Communicating Hydrocephalus in a Case of Long-Term Primary Hyperparathyroidism

      case-report

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          Abstract

          We present the rare case of a 47-year-old woman with protracted primary hyperparathyroidism complicated by communicating hydrocephalus and cerebellar tonsillar herniation secondary to calvarial thickening. The parathyroid glands remained elusive, despite the use of advanced preoperative imaging modalities and three neck explorations. The serum calcium was optimally controlled with cinacalcet and alfacalcidol. Awareness of this rare complication is essential for early diagnosis and prompt intervention to prevent fatal posterior brain herniation.

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          Primary hyperparathyroidism

          Marcella D Walker, Shonni J. Silverberg (2017)
          Primary hyperparathyroidism (PHPT) is a common endocrine disorder characterized by hypercalcaemia and elevated or inappropriately normal serum levels of parathyroid hormone. Here, Walker and Silverberg review the pathogenesis, diagnosis and management of PHPT, focusing on recent advances in the field.
          Article 0 comments Cited 150 times – based on 0 reviews     Review now
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            Clinical review: Parathyroid localization and implications for clinical management.

            John W Kunstman, Jonathan D Kirsch, Amit Mahajan … (2013)
            The prevalence of hyperparathyroidism, especially primary hyperparathyroidism, has increased in recent decades due to improvements in diagnostic techniques with a corresponding surge in parathyroid surgery, leading to the development of focused, minimally invasive surgical approaches. Focused parathyroidectomy is predicated on preoperative localization of suspected parathyroid pathology. As a result, there has been a proliferation of parathyroid imaging modalities and protocols, resulting in confusion about their indications and applications.
            Article 0 comments Cited 39 times – based on 0 reviews     Review now
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              Outcomes of Parathyroidectomy in Patients with Primary Hyperparathyroidism: A Systematic Review and Meta-analysis

              Naykky Singh Ospina, René Rodríguez-Gutiérrez, Spyridoula Maraka … (2016)
              Parathyroidectomy is a definitive treatment for primary hyperparathyroidism. Patients contemplating this intervention will benefit from knowledge regarding the expected outcomes and potential risks of the currently available surgical options.
              Article 0 comments Cited 33 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): J ASEAN Fed Endocr Soc
                Journal ID (iso-abbrev): J ASEAN Fed Endocr Soc
                Journal ID (publisher-id): JAFES
                Title: Journal of the ASEAN Federation of Endocrine Societies
                Publisher: Journal of the ASEAN Federation of Endocrine Societies
                ISSN (Print): 0857-1074
                ISSN (Electronic): 2308-118X
                Publication date (Electronic): 20 April 2018
                Publication date (Print): 2018
                Volume: 33
                Issue: 1
                Pages: 49-52
                Affiliations
                [1 ]Endocrinology Unit, Department of Medicine, Universiti Putra Malaysia
                [2 ]Endocrinology Unit, Department of Medicine, Pusat Perubatan Universiti Kebangsaan Malaysia
                [3 ]Radiology Department, Pusat Perubatan Universiti Kebangsaan Malaysia
                Author notes
                Corresponding address: Cheow Peng Ooi, PhD, Endocrine Unit, Department of Medicine, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Malaysia. Tel. No.: +603- 89472557. E-mail: cpooi2012@ 123456yahoo.com ORCID iD: https://orcid.org/0000-0003-4038-8866
                Article
                Publisher ID: JAFES-33-1-049
                DOI: 10.15605/jafes.033.01.08
                PMC ID: 7784083
                SO-VID: f3c24259-3ff6-43cf-b71e-96771e433af4
                Copyright © © 2018 Journal of the ASEAN Federation of Endocrine Societies
                License:

                This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International.

                History
                Date received : 19 December 2017
                Date accepted : 06 March 2018
                Categories
                Subject: Case Report

                Keywords: cinacalcet,hydrocephalus,hypercalcemia,hyperparathyroidism,primary,osteitis fibrosis cystica
                Data availability:
                Keywords: cinacalcet, hydrocephalus, hypercalcemia, hyperparathyroidism, primary, osteitis fibrosis cystica

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