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      Chip integrated strategies for acoustic separation and manipulation of cells and particles.

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          Abstract

          Acoustic standing wave technology combined with microtechnology opens up new areas for the development of advanced particle and cell separating microfluidic systems. This tutorial review outlines the fundamental work performed on continuous flow acoustic standing wave separation of particles in macro scale systems. The transition to the microchip format is further surveyed, where both fabrication and design issues are discussed. The acoustic technology offers attractive features, such as reasonable throughput and ability to separate particles in a size domain of about tenths of micrometers to tens of micrometers. Examples of different particle separation modes enabled in microfluidic chips, utilizing standing wave technology, are described along a discussion of several potential applications in life science research and in the medical clinic. Chip integrated acoustic standing wave separation technology is still in its infancy and it can be anticipated that new laboratory standards very well may emerge from the current research.

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          Author and article information

          Journal
          Chem Soc Rev
          Chemical Society reviews
          Royal Society of Chemistry (RSC)
          0306-0012
          0306-0012
          Mar 2007
          : 36
          : 3
          Affiliations
          [1 ] Dept. Electrical Measurements, Lund University, P.O. Box 118, S-221 00, Lund, Sweden.
          Article
          10.1039/b601326k
          17325788
          f3c9d05b-0ccd-4778-93ba-dc113c25b192
          History

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