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      Stimulated thyroglobulin values above 5.6 ng/ml before radioactive iodine ablation treatment following levothyroxine withdrawal is associated with a 2.38-fold risk of relapse in Tg-ab negative subjects with differentiated thyroid cancer.

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          Abstract

          Serum thyroglobulin (Tg) is the key parameter used in the follow-up of subjects with differentiated thyroid cancer (DTC). Current guidelines advise its measurement to take place when Thyrotropin (TSH) levels are >30 µU/ml (stimulated Tg) and when TSH < 0.1 µU/ml (suppressed Tg). Although stimulated Tg levels <1 ng/ml have been shown to display excellent prognosis, relapses may occur despite low Tg levels. Recently, very low cut-off levels of stimulated Tg have been proposed for determining the recurrence risk in these subjects. In this study, we aimed to assess the association between ablative stimulated Tg obtained before radioactive iodine ablation therapy (RAI) (ASTg) and late stimulated Tg obtained 6-12 months after primary therapy (LSTg) in a group of subjects with DTC. We also aimed to establish a cut-off level of Tg for recurrence.

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          Author and article information

          Journal
          Clin Transl Oncol
          Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
          Springer Nature America, Inc
          1699-3055
          1699-048X
          August 2017
          : 19
          : 8
          Affiliations
          [1 ] Department of Endocrinology and Metabolism, Baskent University School of Medicine, 5. Sokak No 48 Bahcelievler-Cankaya, Ankara, Turkey. umutmousa@yahoo.co.uk.
          [2 ] Department of Internal Medicine, Baskent University School of Medicine, Ankara, Turkey.
          [3 ] Department of Endocrinology and Metabolism, Baskent University School of Medicine, 5. Sokak No 48 Bahcelievler-Cankaya, Ankara, Turkey.
          Article
          10.1007/s12094-017-1640-3
          10.1007/s12094-017-1640-3
          28258491

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