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      Guidelines for the treatment of bacterial vaginosis: focus on tinidazole

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          Abstract

          Bacterial vaginosis (BV) is a complex vaginal infection most commonly associated with women of child-bearing age. Risk factors for BV are numerous. There are currently multiple clinical and laboratory tests for diagnosis of BV, including the most commonly used diagnostic methods: Amsel’s criteria or Nugent’s Gram stain scale. The mainstay of BV therapy is metronidazole, but tinidazole as well as a few other agents have also been used successfully. Tinidazole is the second nitroimidazole antiprotozoal agent and a structural derivative of metronidazole. With a favorable pharmacokinetic profile and reduced side effects, tinidazole is an alternative agent for BV treatment. There are minimal head-to-head comparative data to establish tinidazole’s superiority to metronidazole or other therapeutic agents. Available data suggest tinidazole has a role in special populations particularly for refractory or relapsing BV.

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          Author and article information

          Journal
          Ther Clin Risk Manag
          Therapeutics and Clinical Risk Management
          Therapeutics and Clinical Risk Management
          Dove Medical Press
          1176-6336
          1178-203X
          2009
          2009
          12 July 2009
          : 5
          : 485-489
          Affiliations
          [1 ] Department of Pharmacy Services, Detroit Receiving Hospital, Detroit, MI, USA
          [2 ] University of Connecticut, School of Pharmacy, Storrs, CT, USA
          [3 ] Hartford Hospital, Department of Pharmacy, Hartford, CT, USA
          [4 ] Wayne State University, School of Medicine, Detroit, MI, USA
          Author notes
          Correspondence: Jack D Sobel, Chief, Division of Infectious Diseases, Professor of Medicine, Wayne State University, Detroit, MI, USA, Tel +1 313 745 9131, Fax +1 313 993 0302, Email jsobel@ 123456med.wayne.edu
          Article
          tcrm-5-485
          2710380
          19707258
          © 2009 Dickey et al, publisher and licensee Dove Medical Press Ltd.

          This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

          Categories
          Review

          Medicine

          gardnerella, vaginosis, bacterial vaginosis, tinidazole

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