Gonadotropin-Releasing Hormone Neuroblasts from One Olfactory Placode Can Be Present in Both Hemispheres in the Clawed Toad  Xenopus laevis

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Abstract

Ontogenetic differentiation of the GnRH-immunoreactive (GnRHir) neuron system was studied in the clawed toad Xenopus laevis by immunocytochemistry employing polyclonal antibodies against mammalian GnRH and chicken type II GnRH, and monoclonal antibodies against GnRH exhibiting wide cross-reactivity over animal classes. Toads at different stages of differentiation as well as postmetamorphic toads subjected to uni- or bilateral ablation of the olfactory placode (OPX) between developmental stages 25 and 30 were studied. GnRHir neurons and nerve fibers could not be detected before metamorphosis. Following metamorphosis, at stage 65–66, hemi-OPX toads did not exhibit any side differences in the number and overall distribution of the GnRHir neuronal structures; however, the total number of GnRHir neurons was approximately 50% of that counted in intact controls at the same developmental stages. These findings indicate that GnRHir neuroblasts differentiating on one side in the olfactory placode can appear on both sides of the brain in the course of their migration.

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Journal

Journal ID (publisher-id): NEN

Journal ID (nlm-ta): Neuroendocrinology

Journal ID (doi): 10.1159/issn.0028-3835

Title: Neuroendocrinology

Publisher: S. Karger AG

ISSN (Print): 0028-3835

ISSN (Electronic): 1423-0194

Publication date Subscription-year: 1996

Publication date (Print): 1996

Publication date (Electronic): 09 April 2008

Volume: 63

Issue: 5

Pages: 408-414

Affiliations

Department of Anatomy, Histology and Embryology, University Medical School, Pécs, Hungary

Article

Publisher ID: 127066 Other ID: Neuroendocrinology 1996;63:408–414

DOI: 10.1159/000127066

PubMed ID: 8738577

SO-VID: f3d41d15-ceac-4bed-88c0-b4ee18b8f476

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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

History

Date received : 21 July 1995

Date accepted : 11 December 1995

Page count

Pages: 7

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Gonadotropin-Releasing Hormone Neuroblasts from One Olfactory Placode Can Be Present in Both Hemispheres in the Clawed Toad Xenopus laevis

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