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      Antielastin autoimmunity in tobacco smoking-induced emphysema.

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          Abstract

          Chronic obstructive pulmonary disease and emphysema are common destructive inflammatory diseases that are leading causes of death worldwide. Here we show that emphysema is an autoimmune disease characterized by the presence of antielastin antibody and T-helper type 1 (T(H)1) responses, which correlate with emphysema severity. These findings link emphysema to adaptive immunity against a specific lung antigen and suggest the potential for autoimmune pathology of other elastin-rich tissues such as the arteries and skin of smokers.

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          Author and article information

          Journal
          Nat. Med.
          Nature medicine
          Springer Nature
          1078-8956
          1078-8956
          May 2007
          : 13
          : 5
          Affiliations
          [1 ] Department of Medicine, Section of Pulmonary and Critical Care, Baylor College of Medicine, Houston, Texas 77030, USA.
          Article
          nm1583
          10.1038/nm1583
          17450149

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