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      Participation of lipid peroxidation in rat pertussis vaccine pleurisy. III. Thiobarbituric acid (TBA) reactant and lysosomal enzyme.

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          Abstract

          Activity of lysosomal enzymes, such as N-acetyl-beta-D-glucosaminidase (NAG), was assayed in exudate on a rat model of Bordetella pertussis vaccine pleurisy. Thiobarbituric acid (TBA)-reactive substances (TBA.R) and superoxide dismutase (SOD) activity were then monitored in the exudate on the acute phase response in this inflammatory model. Retention of the exudate in the pleural space increased rapidly after the challenge, and the exudate volume at 24 h reached about three times the volume at 6 h. The activity of SOD at 6 h was shown to be higher than that at 24 h after the challenge, thus showing negative correlations with TBA-R levels and exudate volume. The levels of TBA.R rapidly increased and reached maximum values at 24 h. It was concluded that the above three parameters correlated to the acute phase response in this inflammatory model.

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          Author and article information

          Journal
          Chem. Pharm. Bull.
          Chemical & pharmaceutical bulletin
          0009-2363
          0009-2363
          Feb 1991
          : 39
          : 2
          Affiliations
          [1 ] Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., Yokohama, Japan.
          Article
          2054877
          f3ed4c53-3584-4570-87e8-9dde8e64b0db
          History

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