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      Varicella myopericarditis mimicking acute myocardial infarction with ARDS – A rare association in an immunocompetent young adult

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          Abstract

          Primary varicella infection in an immunocompetent young adult is very rare, but it has a high mortality rate due to serious complications. We report a rare association of varicella pneumonia presenting in acute respiratory distress with mild chest pain, however with electrocardiographic and biochemical markers suggestive of acute ST elevation myocardial infarction. Coronary angiography was done to exclude infarction, serum antibody titers confirmed varicella, acyclovir was started, and ARDS was successfully treated with steroid pulse therapy and mechanical ventilator support. Early administration of antivirals and aggressive management of ARDS were thought to be necessary to overcome the potential life-threatening complications of varicella infection in adults. This case illustrates that not every MI is really MI.

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          Varicella myopericarditis mimicking myocardial infarction in a 17-year-old boy.

          Varicella (chickenpox), a common childhood infection caused by the varicella-zoster virus, is self-limiting and usually benign. Although atypical manifestations of the virus are occasionally seen, it rarely presents with cardiovascular sequelae. Cardiovascular complications of varicella can include pericarditis, myocarditis, or endocarditis. Herein, we report the case of a 17-year-old boy who had varicella infection and severe chest pain. Examination revealed atypical electrocardiographic findings of pericarditis and remarkably elevated cardiac biomarker levels: peak cardiac troponin I, 37.2 ng/mL; total creatine kinase, 1,209 U/L; and creatine kinase-MB fraction, 133.6 ng/mL. After results of coronary angiography reliably excluded ischemia and myocardial infarction, the diagnosis was varicella myopericarditis. The patient was placed on a medical regimen during and after 5 days of hospitalization. In 2 weeks, he was asymptomatic, and at 6 months, he was doing well and had normal electrocardiographic and echocardiographic results.To our knowledge, cardiac enzyme elevations to these levels have not been reported in cases of cardiovascular sequelae of varicella. We discuss the diagnostic challenges of this atypical case and suggest that clinicians be aware that varicella disease is most often, but not always, benign.
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            When an MI Is Not an MI: A Case of Varicella Zoster Myocarditis

            A sixteen-year-old male presented with symptoms and investigations suggestive of acute myocardial infarction. The patient had suffered from a varicella zoster infection 5 days prior to presentation. Varicella myocarditis was suspected and diagnosed following treatment and positive varicella serology. This case highlights a rare but serious cardiac presentation of a common condition.
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              Author and article information

              Contributors
              Journal
              Indian Heart J
              Indian Heart J
              Indian Heart Journal
              Elsevier
              0019-4832
              September 2016
              20 December 2015
              : 68
              : Suppl 2
              : S274-S275
              Affiliations
              [a ]Senior Resident, Department of Cardiology, VMMC & Safdarjung Hospital, New Delhi 110029, India
              [b ]Assistant Professor, Department of Cardiology, VMMC & Safdarjung Hospital, New Delhi 110029, India
              [c ]Head of Department, Department of Cardiology, VMMC & Safdarjung Hospital, New Delhi 110029, India
              Author notes
              [* ] Corresponding author. cmayuresh24@ 123456gmail.com
              Article
              S0019-4832(15)00370-3
              10.1016/j.ihj.2015.08.026
              5067438
              27751313
              f3f25a2d-3a36-4335-b3ec-3fb3f62c4e09
              © 2015 Cardiological Society of India. Published by Elsevier B.V.

              This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

              History
              : 24 March 2015
              : 18 August 2015
              Categories
              Case Reports

              varicella,myopericarditis,myocardial infarction
              varicella, myopericarditis, myocardial infarction

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