0
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Diverse roles of macrophages in intraocular neovascular diseases: a review

      review-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Macrophages are involved in angiogenesis, and might also contribute to the pathogenesis of intraocular neovascular diseases. Recent studies indicated that macrophages exert different functions in the process of intraocular neovascularization, and the polarization of M1 and M2 phenotypes plays extremely essential roles in the diverse functions of macrophages. Moreover, a large number of cytokines released by macrophages not only participate in macrophage polarization, but also associate with retinal and choroidal neovascular diseases. Therefore, macrophage might be considered as a novel therapeutic target to the treatment of pathological neovascularization in the eye. This review mainly summarizes diverse roles of macrophages and discusses the possible mechanisms in retinal and choroidal neovascularization.

          Related collections

          Author and article information

          Journal
          Int J Ophthalmol
          Int J Ophthalmol
          IJO
          International Journal of Ophthalmology
          International Journal of Ophthalmology Press
          2222-3959
          2227-4898
          18 December 2017
          2017
          : 10
          : 12
          : 1902-1908
          Affiliations
          [1 ] Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China
          [2 ] Hunan Clinical Research Center of Ophthalmic Disease, Changsha 410011, Hunan Province, China
          [3 ] Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan
          Author notes
          Correspondence to: Ye-Di Zhou. Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha 410011, Hunan Province, China. zhouyedi@ 123456csu.edu.cn ; Shigeo Yoshida. Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, Fukuoka 812-8582, Japan. yosida@ 123456med.kyushu-u.ac.jp
          Article
          PMC5733520 PMC5733520 5733520 ijo-10-12-1902
          10.18240/ijo.2017.12.18
          5733520
          29259911
          f3f588bb-d9ad-4784-bda5-9fd5e8f44779
          International Journal of Ophthalmology Press
          History
          : 23 April 2017
          : 6 November 2017
          Categories
          Review

          retinopathy of prematurity,age-related macular degeneration,proliferative diabetic retinopathy,choroidal neovascularization,retinal neovascularization,macrophage

          Comments

          Comment on this article