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      Effects of Arteriovenous Fistula Ligation on Cardiac Structure and Function in Kidney Transplant Recipients

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            Natriuretic peptide hormones, a family of vasoactive peptides with many favourable physiological properties, have emerged as important candidates for development of diagnostic tools and therapeutic agents in cardiovascular disease. The rapid incorporation into clinical practice of bioassays to measure natriuretic peptide concentrations, and drugs that augment the biological actions of this system, show the potential for translational research to improve patient care. Here, we focus on the physiology of the natriuretic peptide system, measurement of circulating concentrations of B-type natriuretic peptide (BNP) and the N-terminal fragment of its prohormone (N-terminal BNP) to diagnose heart failure and left ventricular dysfunction, measurement of BNP and N-terminal BNP to assess prognosis in patients with cardiac abnormalities, and use of recombinant human BNP (nesiritide) and vasopeptidase inhibitors to treat heart failure.
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                Author and article information

                Journal
                Circulation
                Circulation
                Ovid Technologies (Wolters Kluwer Health)
                0009-7322
                1524-4539
                June 18 2019
                June 18 2019
                : 139
                : 25
                : 2809-2818
                Affiliations
                [1 ]Adelaide Medical School, University of Adelaide, Australia (N.N.R., S.U., R.P.C., S.P.M., M.I.W., P.T.C.).
                [2 ]Central Northern Adelaide Renal and Transplantation Service (N.N.R., D.K., E.M., C.H.R., S.O., R.P.C., R.J.F., S.P.M., P.T.C.), Central Adelaide Local Health Network, Australia.
                [3 ]Lyell McEwin Hospital, Northern Adelaide Local Health Network, Australia (N.N.R.).
                [4 ]Department of Cardiology (M.B.S., A.R., K.W., K.S.L.T., M.I.W.), Central Adelaide Local Health Network, Australia.
                [5 ]Department of Cardiology, Royal Perth Hospital, Australia (A.R.).
                [6 ]Australia and New Zealand Dialysis and Transplant Registry 1 (S.U., S.P.M.), South Australian Health and Medical Research Institute, Adelaide.
                [7 ]Department of Vascular Surgery (D.K., E.M.), Central Adelaide Local Health Network, Australia.
                [8 ]Heart Health Theme (M.I.W.), South Australian Health and Medical Research Institute, Adelaide.
                Article
                10.1161/CIRCULATIONAHA.118.038505
                31045455
                f3fb2b4b-99aa-4969-95d0-d76658be268d
                © 2019
                History

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