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      Prevalence of serrated polyposis syndrome and its association with synchronous advanced adenoma and lifestyle.

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          Abstract

          We assessed the clinicopathological characteristics of patients with serrated polyposis syndrome (SPS) and the incidence of advanced adenoma/colorectal cancer (CRC). We prospectively enrolled 249 consecutive patients who underwent colonoscopy at the National Cancer Center Hospital over a 6-month period. All the polyps were diagnosed using magnification colonoscopy and resection/biopsy. The enrolled patients were divided into two groups, i) those with ≥5 histologically diagnosed hyperplastic polyps (HPs) proximal to the sigmoid colon, with at least 2 polyps >10 mm in diameter and ii) those with ≥20 HPs distributed throughout the colon. The clinical characteristics of the two groups were compared, including lifestyle, family history of CRC and colonoscopic findings. HPs were identified in 228 patients, of whom 21 (8.4%) had SPS. All 21 patients had ≥20 HPs distributed throughout the colon, with none having >2 HPs ≥1 cm in diameter in the right colon. Synchronous advanced adenoma/CRC was diagnosed in 76/249 (30.5%) patients. The prevalence of advanced adenoma/CRC was higher among patients with compared to those without SPS (P=0.075). SPS was also associated with older age and higher body mass index (BMI). Our results suggested that older age and higher BMI are independent risk factors for SPS. Advanced adenoma/CRC tended to occur more frequently among patients with compared to those without SPS, although the difference was not statistically significant.

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          Author and article information

          Journal
          Mol Clin Oncol
          Molecular and clinical oncology
          Spandidos Publications
          2049-9450
          2049-9450
          Jan 2015
          : 3
          : 1
          Affiliations
          [1 ] Endoscopy Division, National Cancer Center Hospital, Tokyo 104-0045, Japan ; Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224-8503, Japan.
          [2 ] Endoscopy Division, National Cancer Center Hospital, Tokyo 104-0045, Japan.
          [3 ] Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
          [4 ] Division of Molecular Pathology, National Cancer Center Research Institute, Tokyo 104-0061, Japan.
          [5 ] TF Clinic, Tokyo 104-0061, Japan.
          [6 ] Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Kanagawa 224-8503, Japan.
          Article
          mco-03-01-0069
          10.3892/mco.2014.423
          4251102
          25469272

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