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      Water Metabolism in Rats Subjected to Chronic Alcohol Administration

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          Aim: While the diuretic action of acute ingestion of alcohol has been studied extensively, the effect of chronic alcohol consumption has received less attention. The aim of the present study was to investigate the effect of chronic alcohol consumption on the balance of water intake and excretion and certain renal functions in rats during a period of 12 months. Animals and Study Design: Male Wistar rats received either alcohol (15% v/v; group A, n = 65) or tap water (group C, n = 35) as drinking fluid. Urine and faeces were collected from 6 rats of each group during 7 days, at monthly intervals. In further experiments, the animals received a low-protein/high-fat diet with and without alcohol. Results: When the rats were fed the standard diet, 24-hour urine excretion was significantly reduced in group A compared with group C. This difference was even more pronounced when the animals were fed the low-protein/high-fat diet. The reduced urine excretion was not due to lower liquid consumption and the pattern of daily excretion of faeces was comparable with that observed for urine excretion. Both sodium and potassium excretion and the diuretic response to an acute water load were significantly reduced in group A compared with group C. The changes in water balance induced by chronic alcohol consumption were reversible within a few days when the rats received water instead of 15% alcohol. Conclusions: Chronic alcohol consumption has an antidiuretic effect in rats. The percentage of total ingested fluid leaving the body as hidden water loss increases after alcohol consumption by up to 25–26% over control values.

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          Models of alcoholic liver disease in rodents: a critical evaluation.

          This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were J. Christian Bode and Hiroshi Fukui. The presentations were (1) Essentials and the course of the pathological spectrum of alcoholic liver disease in humans, by P. de la M. Hall; (2) Lieber-DeCarli liquid diet for alcohol-induced liver injury in rats, by C. S. Lieber and L. M. DeCarli; (3) Tsukamoto-French model of alcoholic liver injury, by S. W. French; (4) Animal models to study endotoxin-ethanol interactions, by K. O. Lindros and H. Järveläinen; and (5) Jejunoileal bypass operation in rats-A model for alcohol-induced liver injury? by Christiane Bode, Alexandr Parlesak, and J. Christian Bode.
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            A possible role of atrial natriuretic peptide in ethanol-induced acute diuresis


              Author and article information

              Nephron Physiol
              Nephron Physiology
              S. Karger AG
              May 2004
              24 May 2004
              : 97
              : 1
              : p9-p15
              aDepartment of Physiology of Nutrition, Hohenheim University, and bDepartment of Internal Medicine I, Division of Gastroenterology and Hepatology, Robert Bosch Hospital, Stuttgart, Germany
              77597 Nephron Physiol 2004;97:p9–p15
              © 2004 S. Karger AG, Basel

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              Page count
              Figures: 5, Tables: 2, References: 23, Pages: 1
              Self URI (application/pdf):
              Original Paper

              Cardiovascular Medicine, Nephrology

              Water metabolism, Renal function, Diuresis, Potassium, Alcohol, Uric acid, Sodium


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