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      TOX gene: a novel target for human cancer gene therapy.

      1 , 2
      American journal of cancer research
      TOX, apoptosis, cancer, oncogene, proliferation

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          Abstract

          Thymocyte selection-associated high mobility group box factor (TOX) is a member of an evolutionarily conserved DNA-binding protein family and is expressed in several immune-relevant cell subsets. TOX encodes a nuclear protein of the high-mobility group box superfamily. It contains a DNA-binding domain, which allows it to regulate transcription by modifying local chromatin structure and modulating the formation of multi-protein complexes. Previous studies have shown that TOX play important roles in immune system. More recently, several studies have described TOX expression is frequently upregulated in diverse types of human tumors and the overregulation often associates with tumor progression. Moreover, TOXis involved in the control of cell apoptosis, growth, metastasis, DNA repair and so on. In this review, we provide an overview of current knowledge concerning the role of TOX in tumor development and progression biology function. To our knowledge, this is the first review about the role of thisnew oncogene in tumor development and progression.

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          Author and article information

          Journal
          Am J Cancer Res
          American journal of cancer research
          2156-6976
          2156-6976
          2015
          : 5
          : 12
          Affiliations
          [1 ] Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100042, China.
          [2 ] Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, China.
          Article
          4731627
          26885442
          f4393599-cd55-471e-abcc-f93dc810e7ba
          History

          cancer,apoptosis,TOX,oncogene,proliferation
          cancer, apoptosis, TOX, oncogene, proliferation

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