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      Ketamine gargle for attenuating postoperative sore throat.

      BJA: British Journal of Anaesthesia

      Single-Blind Method, Adolescent, Severity of Illness Index, Rhinoplasty, antagonists & inhibitors, Receptors, N-Methyl-D-Aspartate, Prospective Studies, prevention & control, Postoperative Complications, etiology, Pharyngitis, Mouthwashes, Male, therapeutic use, administration & dosage, Ketamine, adverse effects, Intubation, Intratracheal, Humans, Female, Excitatory Amino Acid Antagonists, Anesthesia, General, Adult

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          Abstract

          Tracheal intubation is a foremost cause of trauma to the airway mucosa, resulting in postoperative sore throat (POST) with reported incidences of 21-65%. We compared the effectiveness of ketamine gargles with placebo in preventing POST after endotracheal intubation. Forty-six, ASA I-II, patients undergoing elective surgery for septorhinoplasty under general anaesthesia were enrolled in this prospective, randomized, placebo-controlled, single-blind study. Patients were randomly allocated into two groups of 23 subjects each: Group C, saline 30 ml; Group K, ketamine 40 mg in saline 30 ml. Patients were asked to gargle this mixture for 30 s, 5 min before induction of anaesthesia. POST was graded at 0, 2, 4, and 24 h after operation on a four-point scale (0-3). POST occurred more frequently in Group C, when compared with Group K, at 0, 2, and 24 h and significantly more patients suffered severe POST in Group C at 4 and 24 h compared with Group K (P<0.05). Ketamine gargle significantly reduced the incidence and severity of POST.

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          Journal
          10.1093/bja/aen023
          18310675

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