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      Studies on the Involvement of Melatonergic Mechanism in Intraocular Pressure Regulation

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          It has been reported that diurnal changes in intraocular pressure (IOP) may be related to the fluctuation of melatonin levels in the eye. In order to test this hypothesis, effects of methysergide, tranylcypromine, and p-chlorophenylalanine (PCPA) on IOP recovery were studied in rabbits infused with hypertonic saline. Methysergide, a serotonin blocker at receptor sites, did not affect IOP recovery, presumably because it did not affect melatonin synthesis. Tranylcypromine, a monoamine oxidase inhibitor which preserves serotonin and eventually increases the level of melatonin in tissues, facilitated IOP recovery. PCPA, known to inhibit serotonin synthesis and to lower the melatonin level in tissues, markedly delayed IOP recovery. These results indicate that a chemical which decreases melatonin content in the eye also lowers the IOP and vice versa. It is suggested that some melatonergic mechanism is involved in the circadian rhythm of IOP.

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          Author and article information

          Ophthalmic Res
          Ophthalmic Research
          S. Karger AG
          04 December 2009
          : 16
          : 6
          : 302-306
          Department of Medical Pharmacology and Toxicology, Texas A & M University College of Medicine, College Station, Tex., USA
          265334 Ophthalmic Res 1984;16:302–306
          © 1984 S. Karger AG, Basel

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          Pages: 5
          Original Paper


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