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      The diverse role of the PPARγ coactivator 1 family of transcriptional coactivators in cancer

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      Seminars in cell & developmental biology

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          Abstract

          The critical role that altered cellular metabolism plays in promoting and maintaining the cancer phenotype has received considerable attention in recent years. For many years it was believed that aerobic glycolysis, also known as the Warburg Effect, played an important role in cancer. However, recent studies highlight the requirement of mitochondrial function, oxidative phosphorylation and biosynthetic pathways in cancer. This has promoted interest into mechanisms controlling these metabolic pathways. The PPARγ coactivator (PGC)-1 family of transcriptional coactivators have emerged as key regulators of several metabolic pathways including oxidative metabolism, energy homeostasis and glucose and lipid metabolism. While PGC-1s have been implicated in a number of metabolic diseases, recent studies highlight an important role in cancer. Studies show that PGC-1s have both pro and anticancer functions and suggests a dynamic role for the PGC-1s in cancer. We discuss in this review the links between PGC-1s and cancer, with a focus on the most well studied family member, PGC-1α.

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          Author and article information

          Journal
          9607332
          20707
          Semin Cell Dev Biol
          Semin. Cell Dev. Biol.
          Seminars in cell & developmental biology
          1084-9521
          1096-3634
          1 March 2012
          21 January 2012
          June 2012
          01 June 2013
          : 23
          : 4
          : 381-388
          Affiliations
          Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Department of Biochemistry and Molecular Biology, Baltimore MD. 21201
          Author notes
          To whom correspondence should be addressed: Geoffrey Girnun, PhD Assistant Professor Department of Biochemistry and Molecular Biology University of Maryland Greenebaum Cancer Center 655 W Baltimore St. BRB Room 10-039 Baltimore MD. 21201 Tel. 410-706-3331 Fax. 410-706-3278 ggirnun@ 123456som.umaryland.edu
          Article
          PMC3369022 PMC3369022 3369022 nihpa355672
          10.1016/j.semcdb.2012.01.007
          3369022
          22285815
          f458b26d-233c-4028-9193-3e81422a24f1
          © 2012 Elsevier Ltd. All rights reserved.
          History
          Funding
          Funded by: National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK
          Award ID: K01 DK064685-06 || DK
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          Article

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