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      MicroRNA-mediated feedback and feedforward loops are recurrent network motifs in mammals.

      1 , ,
      Molecular cell
      Elsevier BV

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          Abstract

          MicroRNAs (miRNAs) are regulatory molecules that participate in diverse biological processes in animals and plants. While thousands of mammalian genes are potentially targeted by miRNAs, the functions of miRNAs in the context of gene networks are not well understood. Specifically, it is unknown whether miRNA-containing networks have recurrent circuit motifs, as has been observed in regulatory networks of bacteria and yeast. Here we develop a computational method that utilizes gene expression data to show that two classes of circuits-corresponding to positive and negative transcriptional coregulation of a miRNA and its targets-are prevalent in the human and mouse genomes. Additionally, we find that neuronal-enriched miRNAs tend to be coexpressed with their target genes, suggesting that these miRNAs could be involved in neuronal homeostasis. Our results strongly suggest that coordinated transcriptional and miRNA-mediated regulation is a recurrent motif to enhance the robustness of gene regulation in mammalian genomes.

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          Author and article information

          Journal
          Mol Cell
          Molecular cell
          Elsevier BV
          1097-2765
          1097-2765
          Jun 08 2007
          : 26
          : 5
          Affiliations
          [1 ] Department of Physics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
          Article
          S1097-2765(07)00319-X NIHMS25554
          10.1016/j.molcel.2007.05.018
          2072999
          17560377
          f47561d5-e6dd-454c-989b-eed212f939b2
          History

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