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      The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.

      Developmental Cell

      metabolism, Vascular Endothelial Growth Factor A, physiology, Signal Transduction, cytology, Pancreas, Mice, Laminin, Insulin-Secreting Cells, genetics, Insulin, Gene Expression Regulation, Endothelial Cells, Cell Proliferation, Cell Line, anatomy & histology, Blood Vessels, Basement Membrane, Antigens, CD29, Animals

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          Abstract

          Endocrine pancreatic beta cells require endothelial signals for their differentiation and function. However, the molecular basis for such signals remains unknown. Here, we show that beta cells, in contrast to the exocrine pancreatic cells, do not form a basement membrane. Instead, by using VEGF-A, they attract endothelial cells, which form capillaries with a vascular basement membrane next to the beta cells. We have identified laminins, among other vascular basement membrane proteins, as endothelial signals, which promote insulin gene expression and proliferation in beta cells. We further demonstrate that beta1-integrin is required for the beta cell response to the laminins. The proposed mechanism explains why beta cells must interact with endothelial cells, and it may apply to other cellular processes in which endothelial signals are required.

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          Journal
          10.1016/j.devcel.2006.01.015
          16516842

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