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Abstract
Single nucleotide polymorphism (SNP) studies and random mutagenesis projects identify
amino acid substitutions in protein-coding regions. Each substitution has the potential
to affect protein function. SIFT (Sorting Intolerant From Tolerant) is a program that
predicts whether an amino acid substitution affects protein function so that users
can prioritize substitutions for further study. We have shown that SIFT can distinguish
between functionally neutral and deleterious amino acid changes in mutagenesis studies
and on human polymorphisms. SIFT is available at http://blocks.fhcrc.org/sift/SIFT.html.