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      Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors.

      Science (New York, N.Y.)

      immunology, metabolism, chemistry, genetics, Cell Line, Coculture Techniques, Disease Susceptibility, Evolution, Molecular, Herpesviridae Infections, Histocompatibility Antigens Class I, Antigens, Ly, Hybridomas, Immunity, Innate, Interferon-gamma, biosynthesis, Killer Cells, Natural, Lectins, C-Type, Ligands, Lymphocyte Activation, Membrane Glycoproteins, Mice, Mice, Inbred C57BL, Mice, Inbred Strains, Muromegalovirus, NK Cell Lectin-Like Receptor Subfamily A, Protein Binding, Receptors, Immunologic, Receptors, NK Cell Lectin-Like, Recombinant Fusion Proteins, Transfection, Viral Proteins, 3T3 Cells, Animals

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          Abstract

          Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.

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          Journal
          11950999
          10.1126/science.1070884

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