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      Clinical Characteristics and Outcomes of 905 COVID-19 Patients Admitted to Imam Khomeini Hospital Complex in the Capital City of Tehran, Iran

      1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 8 , 10 , 11 , 10 , 11 , 9 , 9 , 8 , 7 , 11 , 2 , 2 , 12 , 13 , 14 , 15 , 14 , 16 , 17 , 18 , 2 , 19 , 20
      Archives of Iranian Medicine
      Maad Rayan Publishing Company

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          Abstract

          Background: We studied the clinical characteristics and outcomes of 905 hospitalized coronavirus disease 2019 (COVID-19) patients admitted to Imam Khomeini Hospital Complex (IKHC), Tehran, Iran. Methods: COVID-19 patients were recruited based on clinical symptoms and patterns of computed tomography (CT) imaging between February 20 and March 19. All patients were tested for the presence of COVID-19 RNA. The Poisson regression model estimated the incidence rate ratio (IRR) for different parameters. Results: The average age (± standard deviation) was 56.9 (±15.7) years and 61.77% were male. The most common symptoms were fever (93.59%), dry cough (79.78%), and dyspnea (75.69%). Only 43.76% of patients were positive for the RT-PCR COVID-19 test. Prevalence of lymphopenia was 42.9% and more than 90% had elevated lactate dehydrogenase (LDH) or C-reactive protein (CRP). About 11% were severe cases, and 13.7% died in the hospital. The median length of stay (LOS) was 3 days. We found higher risks of mortality in patients who were older than 70 years (IRR = 11.77, 95% CI 3.63–38.18), underwent mechanical ventilation (IRR = 7.36, 95% CI 5.06–10.7), were admitted to the intensive care unit (ICU) (IRR = 5.47, 95% CI 4.00–8.38), tested positive on the COVID-19 test (IRR = 2.80, 95% CI 1.64–3.55), and reported a history of comorbidity (IRR = 1.76, 95% CI 1.07–2.89) compared to their corresponding reference groups. Hydroxychloroquine therapy was not associated with mortality in our study. Conclusion: Older age, experiencing a severe form of the disease, and having a comorbidity were the most important prognostic factors for COVID-19 infection. Larger studies are needed to perform further subgroup analyses and verify high-risk groups.

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          Author and article information

          Contributors
          (View ORCID Profile)
          Journal
          aim
          Archives of Iranian Medicine
          Arch Iran Med
          Maad Rayan Publishing Company
          1029-2977
          1735-3947
          November 2020
          November 01 2020
          : 23
          : 11
          : 766-775
          Affiliations
          [1 ]Gastroenterology Ward, Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
          [2 ]Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
          [3 ]Department of Radiation Oncology, Cancer Institute, Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
          [4 ]Radiation Oncology Research Center, Cancer Research Institute, Tehran University of Medical Sciences, Tehran, Iran
          [5 ]Department of Medical-Surgical Nursing and Basic Sciences, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran
          [6 ]Department of Emergency Medicine, Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
          [7 ]Department of Internal Medicine, Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
          [8 ]Department of Anesthesiology and Intensive Care, Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
          [9 ]Department of Infectious Diseases and Tropical Medicine, Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
          [10 ]Department of Pulmonology, Imam Khomeini Hospital Complex (IKHC), Tehran University of Medical Sciences, Tehran, Iran
          [11 ]Thoracic Research Center, Tehran University of Medical Sciences, Tehran, Iran
          [12 ]Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran
          [13 ]Department of Radiology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
          [14 ]Liver Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran
          [15 ]Occupational Sleep Research Center, Tehran University of Medical Sciences, Tehran, Iran
          [16 ]Hepatobiliary Surgery and Liver Transplantation Division, Department of General Surgery, Imam Khomeini Hospital Complex, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
          [17 ]Department of Environmental Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
          [18 ]Center for Air Pollution Research (CAPR), Institute for Environmental Research (IER), Tehran University of Medical Sciences, Tehran
          [19 ]Cancer Biology Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
          [20 ]Breast Diseases Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran
          Article
          10.34172/aim.2020.102
          33220695
          f4b1ea5a-7e5f-4cff-9735-6dbbe5b75345
          © 2020
          History

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