21
views
0
recommends
+1 Recommend
2 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found

      Telogen effluvium related to post severe Sars‐Cov‐2 infection: Clinical aspects and our management experience

      research-article

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Telogen effluvium (TE) is one of the most common form of hair loss in women. Many triggers have been identified, as stress, drugs, trauma, endocrine disease, nutritional deficiencies, and febrile states. We report three cases of TE occurred after severe Sars‐Cov‐2 infection and provide our clinical management, according to Sars‐Cov‐2 hygiene measures. Only one case report has been found in the literature associating anagen effluvium during severe Sars‐Cov‐2 infection. Other studies reported the exacerbation of a preexisting TE, correlated to the stress of lockdown. In our cases, patients never had a TE diagnosis before and did not report previous evident hair loss. TE can be associated with post severe Sars‐Cov‐2 infection. From our revision of the literature, this is the first case‐series describing TE in post severe Sars‐Cov‐2 patients. Further studies are needed to evaluate the relationship between TE and Sars‐Cov‐2 infection.

          Related collections

          Most cited references30

          • Record: found
          • Abstract: found
          • Article: not found

          The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

          Summary Cytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration of some patients has been closely related to the cytokine storm in their bodies. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.
            Bookmark
            • Record: found
            • Abstract: found
            • Article: found

            COVID‐19‐associated immune thrombocytopenia

            Abstract Thrombocytopenia is a risk factor for increased morbidity and mortality in patients with the new severe acute respiratory syndrome corona virus, SARS‐CoV‐2 infection (COVID‐19 infection).1 Thrombocytopenia in COVID‐19 patients may be caused by disseminated intravascular coagulation (DIC), sepsis or drug‐induced. Recently a single case report suggested immune thrombocytopenia (ITP) may be associated with COVID‐19 infection.2 ITP is a rare autoimmune disease characterized by a platelet count < 100x109/L, leading to an increased bleeding risk.3 Several risk factors have been described for ITP including environmental (e.g. infection, malignancy and drugs) and genetic predisposition.4 We report here the first case series of three patients with ITP associated with COVID‐19 infection.
              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Minoxidil: mechanisms of action on hair growth.

              We have known for over 30 years that minoxidil stimulates hair growth, yet our understanding of its mechanism of action on the hair follicle is very limited. In animal studies, topical minoxidil shortens telogen, causing premature entry of resting hair follicles into anagen, and it probably has a similar action in humans. Minoxidil may also cause prolongation of anagen and increases hair follicle size. Orally administered minoxidil lowers blood pressure by relaxing vascular smooth muscle through the action of its sulphated metabolite, minoxidil sulphate, as an opener of sarcolemmal KATP channels. There is some evidence that the stimulatory effect of minoxidil on hair growth is also due to the opening of potassium channels by minoxidil sulphate, but this idea has been difficult to prove and to date there has been no clear demonstration that KATP channels are expressed in the hair follicle. A number of in vitro effects of minoxidil have been described in monocultures of various skin and hair follicle cell types including stimulation of cell proliferation, inhibition of collagen synthesis, and stimulation of vascular endothelial growth factor and prostaglandin synthesis. Some or all of these effects may be relevant to hair growth, but the application of results obtained in cell culture studies to the complex biology of the hair follicle is uncertain. In this article we review the current state of knowledge on the mode of action of minoxidil on hair growth and indicate lines of future research.
                Bookmark

                Author and article information

                Contributors
                anna.campanati@gmail.com , a.campanati@staff.univpm.it
                Journal
                Dermatol Ther
                Dermatol Ther
                10.1111/(ISSN)1529-8019
                DTH
                Dermatologic Therapy
                John Wiley & Sons, Inc. (Hoboken, USA )
                1396-0296
                1529-8019
                23 November 2020
                : e14547
                Affiliations
                [ 1 ] Department of Clinical and Molecular Sciences ‐ Dermatological Clinic, Università Politecnica delle Marche Ancona Italy
                [ 2 ] Dipartimento di Scienze Biomediche e Sanità Pubblica, Clinica Malattie Infettive Università Politecnica delle Marche Ancona Italy
                Author notes
                [*] [* ] Correspondence

                Anna Campanati, Dermatology Unit, Department of Clinical and Molecular Sciences, Polytechnic Marche University, Ancona, Italy.

                Email: anna.campanati@ 123456gmail.com , a.campanati@ 123456staff.univpm.it

                Author information
                https://orcid.org/0000-0003-0091-4067
                https://orcid.org/0000-0003-2274-1742
                https://orcid.org/0000-0002-3740-0839
                https://orcid.org/0000-0003-3153-1026
                https://orcid.org/0000-0002-7939-0026
                https://orcid.org/0000-0002-1834-2047
                Article
                DTH14547
                10.1111/dth.14547
                7744849
                33190397
                f4cc8e03-a460-46c4-b6df-5a5df782138e
                © 2020 Wiley Periodicals LLC.

                This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

                History
                : 26 September 2020
                : 06 November 2020
                : 11 November 2020
                Page count
                Figures: 3, Tables: 1, Pages: 6, Words: 3923
                Categories
                Original Article
                Original Articles
                Custom metadata
                2.0
                corrected-proof
                Converter:WILEY_ML3GV2_TO_JATSPMC version:5.9.5 mode:remove_FC converted:17.12.2020

                alopecia,hair disorders,infection‐bacterial/fungal/viral,therapy‐systemic

                Comments

                Comment on this article