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      Zebrafish forebrain and temporal conditioning.

      Philosophical Transactions of the Royal Society B: Biological Sciences

      Animals, Basal Ganglia, anatomy & histology, physiology, Behavior, Animal, Habenula, Larva, Mammals, Models, Animal, Models, Neurological, Neurotransmitter Agents, metabolism, Prosencephalon, Species Specificity, Time Factors, Time Perception, Zebrafish

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          Abstract

          The rise of zebrafish as a neuroscience research model organism, in conjunction with recent progress in single-cell resolution whole-brain imaging of larval zebrafish, opens a new window of opportunity for research on interval timing. In this article, we review zebrafish neuroanatomy and neuromodulatory systems, with particular focus on identifying homologies between the zebrafish forebrain and the mammalian forebrain. The neuroanatomical and neurochemical basis of interval timing is summarized with emphasis on the potential of using zebrafish to reveal the neural circuits for interval timing. The behavioural repertoire of larval zebrafish is reviewed and we demonstrate that larval zebrafish are capable of expecting a stimulus at a precise time point with minimal training. In conclusion, we propose that interval timing research using zebrafish and whole-brain calcium imaging at single-cell resolution will contribute to our understanding of how timing and time perception originate in the vertebrate brain from the level of single cells to circuits.

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          Author and article information

          Journal
          24446496
          3895987
          10.1098/rstb.2012.0462

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