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      Clonal interference and the evolution of RNA viruses.

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          Abstract

          In asexual populations, beneficial mutations that occur in different lineages compete with one another. This phenomenon, known as clonal interference, ensures that those beneficial mutations that do achieve fixation are of large effect. Clonal interference also increases the time between fixations, thereby slowing the adaptation of asexual populations. The effects of clonal interference were measured in the asexual RNA virus vesicular stomatitis virus; rates and average effects of beneficial mutations were quantified.

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          Author and article information

          Journal
          Science
          Science (New York, N.Y.)
          American Association for the Advancement of Science (AAAS)
          0036-8075
          0036-8075
          Sep 10 1999
          : 285
          : 5434
          Affiliations
          [1 ] Institut Cavanilles de Biodiversitat i Biología Evolutiva and Departament de Genètica, Universitat de València, Apartado 22085, 46071 València, Spain.
          Article
          7798
          10.1126/science.285.5434.1745
          10481012
          f4e76cd1-9b63-4659-8a4d-ed18acd0dd5f
          History

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