Oral Versus Nasal High-Flow Bronchodilator Inhalation in Chronic Obstructive Pulmonary DiseaseNotation of prior abstract notification: Parts of the results were presented at ATS congress in 2017 as a thematic poster presentation.
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Abstract
Nasal high flow (NHF) alters breathing patterns, stabilizes fraction of inspired oxygen
(FiO2) during respiratory distress, helps to keep up hemostasis in the airways, and
washes out the upper airways. Particularly the support of inspiratory flow and decrease
in functional dead space are interesting mechanisms of action with regard to aerosol
delivery. Several laboratory investigations have studied aerosol delivery via the
nasal route by using NHF, whereas clinical benefits are poorly evaluated.