Association of Infections and Use of Fluoroquinolones With the Risk of Aortic Aneurysm or Aortic Dissection

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Abstract

Prior observational studies have suggested that fluoroquinolone use may be associated with more than 2-fold increased risk of aortic aneurysm or aortic dissection (AA/AD). These studies, however, did not fully consider the role of coexisting infections and the risk of fluoroquinolones relative to other antibiotics.

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Journal

Title: JAMA Internal Medicine

Abbreviated Title: JAMA Intern Med

Publisher: American Medical Association (AMA)

ISSN (Print): 2168-6106

Publication date (Electronic): September 08 2020

Affiliations

[1 ]Faculty of Pharmacy, National Yang-Ming University School of Pharmaceutical Science, Taipei, Taiwan

[2 ]Institute of Public Health, National Yang-Ming University School of Medicine, Taipei, Taiwan

[3 ]Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

[4 ]Department of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan

[5 ]Institute of Epidemiology and Preventive Medicine, National Taiwan University College of Public Health, Taipei, Taiwan

[6 ]Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

[7 ]Department of Medicine, National Cheng Kung University Medical College, Tainan, Taiwan

[8 ]Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Douliou City, Yunlin County, Taiwan

[9 ]Cardiovascular Center, National Taiwan University Hospital Yunlin Branch, Douliou City, Yunlin County, Taiwan

[10 ]Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts

Article

DOI: 10.1001/jamainternmed.2020.4192

PMC ID: 7489369

PubMed ID: 32897358

SO-VID: f4eff376-aa9a-455c-944c-159dda8af867

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