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      Immunotherapeutic targeting of established sarcoma in Swiss mice by tumor-derived antigen-pulsed NLGP matured dendritic cells is CD8+ T-cell dependent.

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          Abstract

          Neem leaf glycoprotein (NLGP) matures human myeloid and mouse bone marrow-derived dendritic cells (DCs). (NLGP) also therapeutically restricts the mouse established sarcoma growth by activating CD8(+) T cells along with increased proportion of tumor residing CD11c(+) DCs. Here, we intended to find out whether CD8(+) T cells become cytotoxic to sarcoma cells after presentation of sarcoma antigen by NLGP-matured DCs to restrict murine sarcoma growth.

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          Author and article information

          Journal
          Immunotherapy
          Immunotherapy
          Future Medicine Ltd
          1750-7448
          1750-743X
          2014
          : 6
          : 7
          Affiliations
          [1 ] Department of Immunoregulation & Immunodiagnostics, Chittaranjan National Cancer Institute (CNCI), 37, SP Mukherjee Road, Kolkata 700026, India.
          Article
          10.2217/imt.14.53
          25290415

          NLGP, dendritic cells, CD8+ T cells, sarcoma

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