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      Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D 3 signalling

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          Abstract

          Cellular responsiveness to retinoic acid and its metabolites is conferred through two structurally and pharmacologically distinct families of receptors: the retinoic acid receptors (RAR) and the retinoid X receptors (RXR). Here we report that the transcriptional activity of RAR and RXR can be reciprocally modulated by direct interactions between the two proteins. RAR and RXR have a high degree of cooperativity in binding to target DNA, consistent with previous reports indicating that the binding of either RAR or RXR to their cognate response elements is enhanced by factors present in nuclear extracts. RXR also interacts directly with and enhances the binding of nuclear receptors conferring responsiveness to vitamin D3 and thyroid hormone T3; the DNA-binding activities of these receptors are also stimulated by the presence of nuclear extracts. Together these data indicate that RXR has a central role in multiple hormonal signalling pathways.

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          Author and article information

          Journal
          0410462
          6011
          Nature
          Nature
          Nature
          0028-0836
          1476-4687
          19 September 2018
          30 January 1992
          27 September 2018
          : 355
          : 6359
          : 446-449
          Affiliations
          [] Howard Hughes Medical Institute
          [* ] The Salk Institute for Biological Studies, La Jolla, California 920377, USA
          Article
          PMC6159885 PMC6159885 6159885 hhmipa989146
          10.1038/355446a0
          6159885
          1310351
          f4f6b6c1-dae5-4af6-bffd-3b00897e593e
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