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Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida.

Author(s): Priscilla Olsen, F Nkrumah, Anders Christensen, L HVIID, E Lemmich, A Kharazmi, A Sittie

Publication date: 1999-03-31

Keywords: Animals, Anthraquinones, chemistry, pharmacology, Antimalarials, Antiprotozoal Agents, Leishmania major, drug effects, Plasmodium falciparum, Rubiaceae, Structure-Activity Relationship

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Abstract

Anthraquinones have been isolated by bioassay-guided fractionation from Morinda lucida. Structure-activity studies show that an aldehyde group at C-2 and a phenolic hydroxy group at C-3 enhance the activity of the anthraquinones against the growth of Plasmodium falciparum and promastigotes of Leishmania major in vitro.

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PubMed ID:: 10232074

DOI:: 10.1055/s-2006-960473

ScienceOpen disciplines: Chemistry

Keywords: Animals,Anthraquinones,chemistry,pharmacology,Antimalarials,Antiprotozoal Agents,Leishmania major,drug effects,Plasmodium falciparum,Rubiaceae,Structure-Activity Relationship

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ScienceOpen disciplines: Chemistry

Keywords: Animals, Anthraquinones, chemistry, pharmacology, Antimalarials, Antiprotozoal Agents, Leishmania major, drug effects, Plasmodium falciparum, Rubiaceae, Structure-Activity Relationship

Structure-activity studies: in vitro antileishmanial and antimalarial activities of anthraquinones from Morinda lucida.

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Herbal Medicines Journal (Herb Med J)

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