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      Curcumin inhibits the Sortase A activity of the Streptococcus mutans UA159.

      1 , ,
      Applied biochemistry and biotechnology
      Springer Nature

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          Abstract

          Streptococcus mutans (S. mutans) forms part of the commensal microflora and is deemed to be the major pathogen responsible for the generation of dental caries. The enzyme, sortase A enzyme, modulates the surface properties and cariogenicity of S. mutans. Curcumin has been reported to be an inhibitor of Staphylococcus aureus sortase A. In this study, inhibition of a purified S. mutans UA159 sortase A by curcumin was evaluated. Curcumin exerted strong inhibitory activity with a half maximal inhibitory concentration (IC50) of 10.2 ± 0.7 μM which was lower than the minimum inhibitory concentration of 175 μM and the minimum bactericidal concentration of 350 μM. These results indicated that curcumin is a S. mutans UA159 sortase A inhibitor and therefore represents as a promising anticaries agent.

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          Author and article information

          Journal
          Appl. Biochem. Biotechnol.
          Applied biochemistry and biotechnology
          Springer Nature
          1559-0291
          0273-2289
          Sep 2013
          : 171
          : 2
          Affiliations
          [1 ] Center of Stomatology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, No. 1095, Jiefang Road, Wuhan 430030, People's Republic of China, gloriaping@126.com.
          Article
          10.1007/s12010-013-0378-9
          23842671
          f4fb66c4-46b8-4cfa-b27c-20f2f63a4940
          History

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