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      GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer.

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          Abstract

          Effective control of both cell survival and cell proliferation is critical to the prevention of oncogenesis and to successful cancer therapy. Using functional expression cloning, we have identified GAS5 (growth arrest-specific transcript 5) as critical to the control of mammalian apoptosis and cell population growth. GAS5 transcripts are subject to complex post-transcriptional processing and some, but not all, GAS5 transcripts sensitize mammalian cells to apoptosis inducers. We have found that, in some cell lines, GAS5 expression induces growth arrest and apoptosis independently of other stimuli. GAS5 transcript levels were significantly reduced in breast cancer samples relative to adjacent unaffected normal breast epithelial tissues. The GAS5 gene has no significant protein-coding potential but expression encodes small nucleolar RNAs (snoRNAs) in its introns. Taken together with the recent demonstration of tumor suppressor characteristics in the related snoRNA U50, our observations suggest that such snoRNAs form a novel family of genes controlling oncogenesis and sensitivity to therapy in cancer.

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          Author and article information

          Journal
          Oncogene
          Oncogene
          Springer Science and Business Media LLC
          1476-5594
          0950-9232
          Jan 15 2009
          : 28
          : 2
          Affiliations
          [1 ] Institute for Science and Technology in Medicine and School of Life Sciences, Keele University, Staffordshire, UK.
          Article
          onc2008373
          10.1038/onc.2008.373
          18836484
          f50a4840-4229-4ead-9c12-c64e197ea334
          History

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