Biologic Therapies and Risk of Infection and Malignancy in Patients With Inflammatory Bowel Disease: A Systematic Review and Network Meta-analysis.

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Abstract

Safety issues are a major concern for patients considering treatments for inflammatory bowel disease (IBD). We performed a systematic review and meta-analysis to determine whether biologic agents affect the risk of infection or malignancy in adults with IBD.

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Author and article information

Journal

Journal ID (iso-abbrev): Clin. Gastroenterol. Hepatol.

Title: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Publisher: Elsevier BV

ISSN (Electronic): 1542-7714

ISSN (Print): 1542-3565

Publication date (Electronic): Oct 2016

Volume: 14

Issue: 10

Affiliations

[1 ] IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy. Electronic address: sbonovas@gmail.com.

[2 ] IBD Center, Department of Gastroenterology, Humanitas Clinical and Research Center, Milan, Italy.

[3 ] Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain; Centre for Research in Environmental Epidemiology, Barcelona, Spain; Hellenic Center for Disease Control and Prevention, Athens, Greece.

[4 ] Hellenic Center for Disease Control and Prevention, Athens, Greece.

[5 ] Department of Hepato-Gastroenterology and Inserm U954, University Hospital of Nancy, Lorraine University, Vandoeuvre-lès-Nancy, France.

[6 ] Department of Biomedical Sciences, Humanitas University, Milan, Italy.

Article

Publisher Item ID: S1542-3565(16)30197-5

DOI: 10.1016/j.cgh.2016.04.039

PubMed ID: 27189910

SO-VID: f51d4d16-6659-4710-a667-01b3aeeb8807

History

Keywords: Anti-TNF,Antibody,Cancer Risk Factor,Side Effect

Data availability:

Keywords: Anti-TNF, Antibody, Cancer Risk Factor, Side Effect

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