LC-MS/MS Measurement of Parathyroid Hormone-Related Peptide.

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Abstract

Parathyroid hormone-related peptide (PTHrP) is involved in activating pathways, allowing tumor cells to form bone metastases. Measurement of PTHrP is used for the diagnosis and clinical management of patients suspected of hypercalcemia of malignancy. We developed an LC-MS/MS method for measuring PTHrP, established sex-specific reference intervals, and assessed the method's performance.

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Journal

Journal ID (iso-abbrev): Clin. Chem.

Title: Clinical chemistry

ISSN (Electronic): 1530-8561

ISSN (Print): 0009-9147

Publication date (Electronic): Jan 2016

Volume: 62

Issue: 1

Affiliations

[1 ] ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT; Department of Pathology and kushnmm@aruplab.com.

[2 ] ARUP Institute for Clinical and Experimental Pathology, Salt Lake City, UT; Department of Pathology and.

[3 ] Department of Pathology and Department of Medicine, University of Utah, Salt Lake City, UT.

Article

Publisher Item ID: clinchem.2015.244012

DOI: 10.1373/clinchem.2015.244012

PubMed ID: 26578690

SO-VID: f533b6e0-94bc-4a27-9304-4bf9a1b981f6

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