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      Bordetella pertussis isolation in general practice: 1977-79 whooping cough epidemic in West Glamorgan.

      , ,
      The Journal of hygiene
      Cambridge University Press (CUP)

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          Abstract

          Some of the factors influencing the isolation rate of Bordetella pertussis during a whooping cough epidemic in West Glamorgan, Wales, are reported. The organism was isolated from 39% of patients with clinical whooping cough, pernasal swabbing being much more successful than cough plates. Isolation rates were increased in the non-immunized, particularly in the first year of life. Erythromycin and co-trimoxazole significantly reduced the isolation rate of B. pertussis but this did not occur with penicillin. In this study 20% of patients were culture positive 6 weeks after the onset of their infection. It is suggested that the Department of Health and Social Security recommendation of a minimum period of three weeks exclusion of children from school is inadequate. During the epidemic, the proportion of strains of B. pertussis containing antigen 2 more than doubled.

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          Author and article information

          Journal
          J Hyg (Lond)
          The Journal of hygiene
          Cambridge University Press (CUP)
          0022-1724
          0022-1724
          Apr 1983
          : 90
          : 2
          Article
          10.1017/s0022172400028825
          2134260
          6300227
          f53405ca-89dc-4491-85ea-0a73e9b1554f
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