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      Responses of the Internal Carotid Artery to Different Endogenous Vasoconstrictor Substances

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          Abstract

          In order to study the action of serotonin (5-HT), noradrenaline (NA), hypertensin (HT), prostaglandins A<sub>1,</sub> B<sub>1</sub> and E<sub>2</sub> (PGA<sub>1,</sub> PGB<sub>1</sub> and PGE<sub>2</sub>) and vasopressin (VP), internal carotid arteries were isolated in situ from both cerebral and general circulation and perfused continuously with oxygenated Ringers’ bicarbonate solution. The order of potencies of the vasoactive substances when administered intra-arterially was: 5-HT > HT > PGE<sub>2</sub>- > PGB<sub>1</sub> > NA. The relative duration of the constrictor effects was: 5-HT < PGA<sub>1</sub><sup>-</sup> < HT and PGE<sub>2</sub> < PGB<sub>1</sub> and NA < VP. The relaxation index of these substances on the vascular wall was: 5-HT < PGE<sub>2</sub> < HT < PGB<sub>1</sub><sup>-</sup> < NA < PGA<sup>1</sup> < VP. Some of these substances, specifically PGB<sub>1</sub> PGE<sub>2</sub> and VP, frequently caused a residual constriction of the smooth muscle following their dilator effect. The role of these vasoactive substances in the development of vasospasm is discussed.

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          Author and article information

          Journal
          JVR
          J Vasc Res
          10.1159/issn.1018-1172
          Journal of Vascular Research
          S. Karger AG
          1018-1172
          1423-0135
          1979
          1979
          19 September 2008
          : 16
          : 3
          : 126-134
          Affiliations
          Laboratory of Physiology and Pathology of the Cerebral Circulation, I. Beritashvih Institute of Physiology, Georgian Academy of Sciences, Tbilisi
          Article
          158199 Blood Vessels 1979;16:126–134
          10.1159/000158199
          f549af3c-fdfe-4c49-a0cf-624124c0c61d
          © 1979 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          History
          : 27 September 1977
          : 10 April 1978
          Page count
          Pages: 9
          Categories
          Original Paper

          General medicine,Neurology,Cardiovascular Medicine,Internal medicine,Nephrology
          Arterial spasm (vasospasm),Internal carotid artery,Vasoconstriction,Serotonin,Prostaglandins,Noradrenaline,Vasopressin,Hypertensin

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