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Making carbon-nitrogen bonds in biological and chemical synthesis.

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Nature chemical biology

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      Abstract

      The function of many biologically active molecules requires the presence of carbon-nitrogen bonds in strategic positions. The biosynthetic pathways leading to such bonds can be bypassed through chemical synthesis to synthesize natural products more efficiently and also to generate the molecular diversity unavailable in nature.

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      Affiliations
      [1 ] Davenport Research Laboratories, Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, Ontario M5S 3H6, Canada.
      Journal
      Nat. Chem. Biol.
      Nature chemical biology
      1552-4450
      1552-4450
      Jun 2006
      : 2
      : 6
      16710330 nchembio0606-284 10.1038/nchembio0606-284

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