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      Preclinical evaluation of the novel small-molecule integrin alpha5beta1 inhibitor JSM6427 in monkey and rabbit models of choroidal neovascularization.

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          Abstract

          To evaluate the pharmacologic activity and tolerability of JSM6427, a potent and first selective small-molecule inhibitor of integrin alpha5beta1, in monkey and rabbit models of choroidal neovascularization (CNV).

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          Author and article information

          Journal
          Arch. Ophthalmol.
          Archives of ophthalmology (Chicago, Ill. : 1960)
          American Medical Association (AMA)
          1538-3601
          0003-9950
          Oct 2009
          : 127
          : 10
          Affiliations
          [1 ] Jerini AG, Invalidenstrasse 130, 10115 Berlin, Germany. grit.zahn@gmx.net
          Article
          127/10/1329
          10.1001/archophthalmol.2009.265
          19822850

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