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      Plasma prolylcarboxypeptidase (angiotensinase C) is increased in obesity and diabetes mellitus and related to cardiovascular dysfunction.

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          Abstract

          Prolylcarboxypeptidase (PRCP) (angiotensinase C) has 3 major targets, angiotensin II, prekallikrein, and α-melanocyte stimulating hormone(1-13). The truncation of the latter leads to loss in appetite regulation and obesity in experimental animals. The objectives of this study were to purify PRCP from a native source, establish a sensitive immunoassay for PRCP, and relate plasma PRCP concentrations to signs and symptoms of obesity, diabetes mellitus, and cardiovascular dysfunction.

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          Author and article information

          Journal
          Clin. Chem.
          Clinical chemistry
          1530-8561
          0009-9147
          Jul 2012
          : 58
          : 7
          Affiliations
          [1 ] Section of Clinical Chemistry, Department of Medical Sciences, University of Uppsala, Uppsala, Sweden.
          Article
          clinchem.2011.179291
          10.1373/clinchem.2011.179291
          22539806

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