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      Receptor downregulation and multivesicular-body sorting.

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          Abstract

          The sorting of proteins into the inner vesicles of multivesicular bodies is required for many key cellular processes, which range from the downregulation of activated signalling receptors to the proper stimulation of the immune response. Recent advances in our understanding of the multivesicular-body sorting pathway have resulted from the identification of ubiquitin as a signal for the efficient sorting of proteins into this transport route, and from the discovery of components of the sorting and regulatory machinery that directs this complex process.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0072
          1471-0072
          Dec 2002
          : 3
          : 12
          Affiliations
          [1 ] Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA. katzmann.david@mayo.edu
          Article
          nrm973
          10.1038/nrm973
          12461556
          f59695a1-f27f-426a-9056-39aafd759351
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